Eltelbany Moemen, Huang Yuting, Sandhu Preetinder, Akbaryeh Abdul, Iloh Nzube, Tran Dena H, Mikdashi Jamal, Bakhtawar Iram
Department of Internal Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA.
American University of Antigua, College of Medicine, Osbourn, Antigua and Barbuda.
J Community Hosp Intern Med Perspect. 2020 Jun 14;10(3):255-257. doi: 10.1080/20009666.2020.1769421.
Anti-synthetase syndrome (ASS) is characterized by myositis that is associated with progressive interstitial lung disease (ILD). The prognosis of the disease is affected by the type and degree of pulmonary involvement. We report a rare case of ASS with positive Anti-EJ antibody presenting with a combination of recurrent deep vein thrombosis/pulmonary embolism (DVT/PE) and progressive ILD. This case demonstrates the delayed diagnosis of ASS and the association of thromboembolic disease and ASS. Physicians should have a high index of suspicion for ASS, as early diagnosis and management alters the morbidity and prognosis of patients with ASS.
ASS: Anti-synthetase syndrome; Ab: Antibody; Ag: Antigen; ANA: Anti-nuclear antibodies; CK: Creatine kinase; CRP: C-reactive protein; DVT: Deep Vein Thrombosis; ESR: Erythrocyte Sedimentation Rate; ILD: Interstitial lung disease; PE: Pulmonary Embolism; CTA: CT Angiography.
抗合成酶综合征（ASS）的特征是伴有进行性间质性肺病（ILD）的肌炎。该疾病的预后受肺部受累类型和程度的影响。我们报告了一例罕见的抗EJ抗体阳性的ASS病例，该病例表现为复发性深静脉血栓形成/肺栓塞（DVT/PE）和进行性ILD的组合。该病例展示了ASS的延迟诊断以及血栓栓塞性疾病与ASS的关联。医生应对ASS保持高度怀疑指数，因为早期诊断和管理可改变ASS患者的发病率和预后。
ASS：抗合成酶综合征；Ab：抗体；Ag：抗原；ANA：抗核抗体；CK：肌酸激酶；CRP：C反应蛋白；DVT：深静脉血栓形成；ESR：红细胞沉降率；ILD：间质性肺病；PE：肺栓塞；CTA：CT血管造影
