Vege Anusha, Beery Jesse, Kara Areeba
Department of Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Case Rep Rheumatol. 2023 Jan 31;2023:9068597. doi: 10.1155/2023/9068597. eCollection 2023.
Antisynthetase syndrome is a rare autoimmune disease within the subset of idiopathic inflammatory myopathies. The diagnostic criteria include the presence of an aminoacyl-tRNA synthetase antibody, and typical clinical findings, including myositis, mechanic's hands, Raynaud phenomenon, unexplained fever, and interstitial lung disease. We describe a case of a 59-year-old male who presented with a 1-month history of progressive purplish discoloration and pain of the fingertips, dyspnea, cough, weight loss, fatigue, and who developed progressive proximal muscle weakness and dysphagia. Investigations revealed pulmonic valve and mitral valve marantic endocarditis, pulmonary embolism, myositis, organizing pneumonia, and elevation of anti-OJ antibodies. He was diagnosed with antisynthetase syndrome and treated with high dose corticosteroids and mycophenolate mofetil with a fair response.
抗合成酶综合征是特发性炎性肌病亚组中的一种罕见自身免疫性疾病。诊断标准包括存在氨酰tRNA合成酶抗体以及典型的临床特征，包括肌炎、技工手、雷诺现象、不明原因发热和间质性肺病。我们报告一例59岁男性患者，其有1个月的指尖进行性紫绀和疼痛、呼吸困难、咳嗽、体重减轻、疲劳病史，并逐渐出现近端肌无力和吞咽困难。检查发现肺动脉瓣和二尖瓣非细菌性血栓性心内膜炎、肺栓塞、肌炎、机化性肺炎以及抗OJ抗体升高。他被诊断为抗合成酶综合征，并接受了大剂量皮质类固醇和霉酚酸酯治疗，反应尚可。
