Nagai K, Fujii T, Inoue S, Takamura Y, Nakagawa H
Institue for Protein Research, Osaka University, Japan.
Horm Metab Res. 1988 Jan;20(1):37-9. doi: 10.1055/s-2007-1010743.
We have presented evidence suggesting that the suprachiasmatic nucleus (SCN) is involved in central regulation of glucose homeostasis. To elucidate this role of the SCN, we examined the effects of its electrical stimulation on glucose metabolism in male Wistar rats. During and shortly after this stimulation, we observed hyperglycemia associated with enhanced hyperglucagonemia but no immediate hyperinsulinemia. In addition, we detected significant increase in liver glycogen phosphorylase alpha activity and significant decrease in the liver glycogen content. These findings suggest that the SCN is important in control of glucose homeostasis through effects on glucagon and insulin secretions and liver glycogen metabolism.
我们已经提供了证据表明，视交叉上核（SCN）参与葡萄糖稳态的中枢调节。为了阐明SCN的这一作用，我们研究了其电刺激对雄性Wistar大鼠葡萄糖代谢的影响。在这种刺激期间及之后不久，我们观察到与高胰高血糖素血症增强相关的高血糖，但没有立即出现高胰岛素血症。此外，我们检测到肝糖原磷酸化酶α活性显著增加，肝糖原含量显著降低。这些发现表明，SCN通过对胰高血糖素和胰岛素分泌以及肝糖原代谢的影响，在葡萄糖稳态控制中起重要作用。
