Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, Telangana, 500016, India.
Neurol Sci. 2020 Nov;41(11):3015-3020. doi: 10.1007/s10072-020-04695-w. Epub 2020 Aug 31.
Though the COVID-19 pandemic primarily affects pulmonary and cardiorenal functions, many healthcare and its allied groups reported neurological involvement of SARS-CoV-2 in combination with either pre-existing metabolic abnormalities, medical conditions, infections or even chronic to acute inflammatory episodes of the nervous system. The present review provides a fair outlook of the published literature and also the case reports with an emphasis on plausible mechanisms involved in neurological complications of the central and peripheral nervous systems. Awareness on the neuropsychiatric manifestations being discussed in this article should ideally help the medical community in early identification and effective management of potentially life-threatening neurological diseases.
尽管 COVID-19 大流行主要影响肺部和心肺功能,但许多医疗保健及其相关团体报告称,SARS-CoV-2 会与先前存在的代谢异常、医疗状况、感染甚至慢性到急性炎症发作一起影响神经系统。本综述提供了已发表文献的公正观点,以及病例报告,重点介绍了中枢和周围神经系统神经并发症中涉及的合理机制。本文讨论的神经精神表现的认识,应该能够帮助医学界及早发现和有效治疗潜在危及生命的神经系统疾病。