Gazala E, Weitzman S, Weizman Z, Gross J, Bearman J E, Gorodischer R
Division of Pediatrics, Soroka Medical Center, Beer Sheva, Israel.
Isr J Med Sci. 1988 Mar;24(3):175-9.
A randomized ambulatory trial was performed to compare early (6-h) vs. late (24-h) refeeding in acute infantile diarrhea. Ninety infants with mild dehydration were enrolled in the study. Following an initial oral rehydration period (WHO formula), refeeding was introduced using a diet based on either breast milk or cow's milk. Early (n = 53) and late (n = 37) refeeding groups were similar in ethnic background, socioeconomic level, relevant past history, nutritional and clinical state, and stool pathogens. Infants were assessed upon their initial visit, at 24 and 48 h, and at 7 and 14 days thereafter for evaluation of weight, hydration state, stool frequency and need of hospitalization. No significant differences in the above parameters were observed between the two groups. Different patterns of refeeding (breast milk vs. cow's milk) in both early and late refeeding groups showed no significant differences in the features studied. Since the short-term clinical outcome following early refeeding in acute infantile diarrhea is not different from late refeeding, we suggest that early refeeding should be preferred, particularly in developing populations, in order to minimize the adverse nutritional effects of prolonged fasting during recurrent bouts of gastroenteritis.
进行了一项随机门诊试验，以比较急性婴儿腹泻早期（6小时）与晚期（24小时）重新喂养的情况。90名轻度脱水的婴儿参与了该研究。在初始口服补液期（采用世界卫生组织配方）之后，采用基于母乳或牛奶的饮食进行重新喂养。早期（n = 53）和晚期（n = 37）重新喂养组在种族背景、社会经济水平、相关既往史、营养和临床状态以及粪便病原体方面相似。在婴儿初次就诊时、24小时和48小时以及之后的7天和14天对其进行评估，以评估体重、水合状态、粪便频率和住院需求。两组在上述参数方面未观察到显著差异。早期和晚期重新喂养组中不同的重新喂养模式（母乳与牛奶）在所研究的特征方面未显示出显著差异。由于急性婴儿腹泻早期重新喂养后的短期临床结果与晚期重新喂养并无不同，我们建议应优先选择早期重新喂养，尤其是在发展中人群中，以便将反复发生肠胃炎期间长期禁食的不良营养影响降至最低。
