Howard P E, Wilson J W, Ribble G A
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
J Am Vet Med Assoc. 1988 Mar 1;192(5):633-7.
Reports from oral surgeons suggested that packing bone defects with cellulose or collagen stimulated cancellous bone replacement. The study reported here was designed to evaluate a similar method for augmenting the remodeling of cancellous bone defects and graft donor sites. Gelatin sponge was implanted into bony defects created in the proximal humeral metaphysis of 5 adult Beagles after collection of cancellous bone. A similar defect created in the contralateral humerus was left unpacked. Four months after creation of the defect, the dogs were euthanatized, and the surgical sites were evaluated by use of correlated microradiographic and histologic examination. Unpacked sites had filled completely with loosely woven trabecular bone. Remodeling had not taken place in sites packed with gelatin sponge. Gelatin sponge did not elicit any reaction in the surrounding bone, but remained in situ and obstructed new bone formation. Gelatin sponge blocked rather than augmented cancellous bone replacement.
口腔外科医生的报告表明，用纤维素或胶原蛋白填充骨缺损可刺激松质骨替代。本文报道的这项研究旨在评估一种类似的方法，以促进松质骨缺损和移植供区的重塑。在5只成年比格犬的肱骨近端干骺端采集松质骨后，将明胶海绵植入所造成的骨缺损处。对侧肱骨制造的类似缺损则不做填充。缺损形成4个月后，对犬实施安乐死，并通过相关的显微放射照相和组织学检查对手术部位进行评估。未填充的部位已完全被疏松编织的小梁骨填满。填充明胶海绵的部位未发生重塑。明胶海绵在周围骨中未引发任何反应，但仍留在原位并阻碍新骨形成。明胶海绵阻碍而非促进松质骨替代。
