Hôpital Cochin-APHP, Department of Radiology, 27 rue du Fbg St Jacques, 75014, Paris, France.
Hôpital Cochin-APHP, Department of Pathology, 27 rue du Fbg St Jacques, 75014, Paris, France.
Eur J Radiol. 2020 Oct;131:109230. doi: 10.1016/j.ejrad.2020.109230. Epub 2020 Aug 20.
To compare the mean apparent diffusion coefficient (ADCmean) and glandular density of Gleason score (GS) 3 + 3 transition zone prostate cancers (TZ-PCa) with those of the peripheral zone (PZ-PCa).
MATERIAL & METHODS: Seventy-nine men (mean age: 65 ± 6 [SD] years; range: 52-81 years) with 37 TZ-PCa (37/79; 53 %) and 42 PZ-PCa (42/79; 47 %) had prostate MRI before radical prostatectomy. Glandular cell density was semi-quantitatively evaluated in all tumors. ADCmean and glandular cell density of GS3 + 3 TZ-PCa were compared to those of PZ-PCa. ADCmean was correlated to GS in each zone.
ADCmean of GS 3 + 3 tumors was significantly lower in the TZ (728 × 10±52 [SD] mm²/s; range: 670-1060mm²/s) than in the PZ (865 × 10 ±121 [SD] mm²/s; range: 670-1120mm²/s) (p = 0.0007), related to a significantly higher glandular density involving more than 50 % of the tumor in 58 % (7/12) of patients in GS3 + 3 TZ-PCa versus 7.6 % (1/13) in PZ-PCa (p = 0.03). ADCmean of GS3 + 3 TZ-PCa was not significantly different from that of GS 3 + 4 (p = 0.14) or GS>3 + 4 Ca (p = 0.9), whatever the zone of origin. In the PZ, ADCmean of GS 3 + 3-PCa was higher than that of Gleason>3 + 4 PZ-PCa (p = 0.02) and similar to that of GS 3 + 4 PZ-PCa (p = 0.24). Correlation between ADCmean and GS was weak for TZ-PCa (ρ = 0.32; p = 0.04) and moderate for PZ-PCa (ρ = 0.45; p = 0.003).
ADCmean of GS 3 + 3 TZ-PCa is significantly lower than that of GS 3 + 3 PZ-PCa, related to a unique dense histological pattern and reaches that of higher-grade PCa, whatever the zone of origin.
比较 Gleason 评分 3+3 前列腺移行区癌（TZ-PCa）与外周区癌（PZ-PCa）的平均表观扩散系数（ADCmean）和腺体密度。
79 名男性（平均年龄：65±6[SD]岁；范围：52-81 岁）中，37 名为 TZ-PCa（37/79；53%），42 名为 PZ-PCa（42/79；47%），在根治性前列腺切除术前均接受了前列腺 MRI 检查。所有肿瘤的腺体细胞密度均进行半定量评估。比较了 GS3+3 TZ-PCa 的 ADCmean 和腺体细胞密度与 PZ-PCa 的差异。分析了 ADCmean 与每个部位 GS 的相关性。
TZ 中 GS3+3 肿瘤的 ADCmean 显著低于 PZ（728×10±52[SD]mm²/s；范围：670-1060mm²/s）（p=0.0007），这与在 GS3+3 TZ-PCa 中 58%（7/12）的患者中腺体密度显著升高有关，即肿瘤中涉及超过 50%的腺体，而在 PZ-PCa 中仅为 7.6%（1/13）（p=0.03）。GS3+3 TZ-PCa 的 ADCmean 与 GS3+4（p=0.14）或 GS>3+4 Ca（p=0.9）无显著差异，无论肿瘤起源于何处。在 PZ 中，GS3+3-PCa 的 ADCmean 高于 Gleason>3+4 PZ-PCa（p=0.02），与 GS3+4 PZ-PCa 相似（p=0.24）。TZ-PCa 的 ADCmean 与 GS 之间的相关性较弱（ρ=0.32；p=0.04），而 PZ-PCa 的相关性适中（ρ=0.45；p=0.003）。
GS3+3 TZ-PCa 的 ADCmean 明显低于 GS3+3 PZ-PCa，这与独特的致密组织学模式有关，无论肿瘤起源于何处，其 ADCmean 均可达到高级别 PCa 的水平。
