Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA.
Department of Physics, Oakland University, Rochester, MI 48309, USA.
Int J Mol Sci. 2020 Aug 27;21(17):6179. doi: 10.3390/ijms21176179.
Stroke remains the leading cause of adult disability. Post-stroke neurogenesis contributes to functional recovery. As an intrinsic neurorestorative process, it is important to elucidate the molecular mechanism underlying stroke-induced neurogenesis and to develop therapies designed specifically to augment neurogenesis. Epigenetic mechanisms include DNA methylation, histone modification and its mediation by microRNAs and long-non-coding RNAs. In this review, we highlight how epigenetic factors including DNA methylation, histone modification, microRNAs and long-non-coding RNAs mediate stroke-induced neurogenesis including neural stem cell self-renewal and cell fate determination. We also summarize therapies targeting these mechanisms in the treatment of stroke.
中风仍然是成年人残疾的主要原因。中风后的神经发生有助于功能恢复。作为一种内在的神经修复过程，阐明中风诱导神经发生的分子机制并开发专门用于增强神经发生的治疗方法非常重要。表观遗传机制包括 DNA 甲基化、组蛋白修饰及其由 microRNAs 和长非编码 RNA 介导。在这篇综述中，我们强调了包括 DNA 甲基化、组蛋白修饰、microRNAs 和长非编码 RNA 在内的表观遗传因子如何介导中风诱导的神经发生，包括神经干细胞自我更新和细胞命运决定。我们还总结了针对这些机制的治疗方法在中风治疗中的应用。
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