Hassani Y, Ramla S, Zouak A, Ahouansou N, Beltramo G, Pages P-B, Georges M, Bonniaud P
Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence Constitutif des maladies Pulmonaires rares de l'Adulte de Dijon, réseau OrphaLung, Filère RespiFil, Centre Hospitalier Universitaire de Bourgogne, Dijon, France.
Service d'Anatomo-pathologie, Centre Hospitalier Universitaire de Bourgogne, Dijon, France; Université de Bourgogne Franche-Comté, Faculté de médecine, Dijon, France.
Rev Mal Respir. 2020 Nov;37(9):743-747. doi: 10.1016/j.rmr.2020.08.003. Epub 2020 Aug 28.
Sclerosing pneumocytoma is a benign and rare lung tumor affecting epithelial cells. In most cases, patients are asymptomatic and the diagnosis is made on an X ray or a CT scan performed for other enquiry. Sex ratio favors women. Epidemiological studies report that middle-aged Asian women are more frequently affected. Radiological investigations find a solitary nodule or a mass with peripheric localization. When performed, histological analysis shows a tumor composed of at least two of the four following architectures: papillary, sclerosing, hemangiomatous and solid, with two types of cells that can be round or cubic cells.
We report two cases of multiple sclerosing pneumocytoma in two caucasien men. The first patient was asymptomatic, the second complain from moderate dyspnea. A wedge resection was performed in both, allowing diagnosis. Anatomopathology revealed respectively a predominant sclerosing and solid architecture and a sclerosing and papillary architecture. There was no progression of the other concomitant nodules after three years follow-up.
Pneumocytoma is a benign, slow-growing tumor with good prognosis.
硬化性肺细胞瘤是一种影响上皮细胞的良性罕见肺肿瘤。在大多数情况下，患者无症状，诊断通过因其他检查而进行的X线或CT扫描做出。性别比例有利于女性。流行病学研究报告称，中年亚洲女性更常受影响。放射学检查发现孤立性结节或外周定位的肿块。进行组织学分析时，显示肿瘤由以下四种结构中的至少两种组成：乳头状、硬化性、血管瘤样和实性，有两种类型的细胞，可为圆形或立方细胞。
我们报告两例白种男性的多发性硬化性肺细胞瘤。第一例患者无症状，第二例主诉中度呼吸困难。两人均进行了楔形切除术以明确诊断。解剖病理学分别显示主要为硬化性和实性结构以及硬化性和乳头状结构。三年随访后，其他伴随结节无进展。
肺细胞瘤是一种良性、生长缓慢且预后良好的肿瘤。
