Sunakawa K, Ishizuka Y, Saito N, Kawai N, Akita H, Iwata S, Sato Y
Department of Pediatrics, Second Tokyo National Hospital.
Jpn J Antibiot. 1988 Feb;41(2):133-43.
The antibacterial efficacy of ceftriaxone (CTRX) against group B Streptococcus and its clinical efficacy in newborns were examined, and the results obtained are summarized as follows. 1. MIC's of CTRX against 55 strains of B group Streptococcus from the pregnant vagina were 0.10 micrograms/ml or lower. 2. Efficacies of CTRX were good to excellent in 8 cases administered for treatment, 3 cases for prophylaxis and 1 for observation of adverse reactions. Observed adverse reactions included diarrhea in 4 cases and vomiting in 2 cases. As abnormal laboratory parameters, eosinophilia and thrombocytosis were observed in 1 case each. 3. An examination of intestinal bacteria in 9 cases revealed that CTRX gave as much influence to the flora as other third-generation cephems. 4. An examination for the vitamin K deficiency in 11 cases found a prolongation of prothrombin time (PT) in 3 cases and protein induced by vitamin K absence (PIVKA) II positive in 2 cases. 5. Testing of platelet aggregation with adenosine diphosphate (ADP) in 7 cases showed little influence of CTRX.
检测了头孢曲松（CTRX）对B族链球菌的抗菌效力及其在新生儿中的临床疗效，所得结果总结如下。1. CTRX对来自妊娠阴道的55株B族链球菌的最低抑菌浓度（MIC）为0.10微克/毫升或更低。2. 在8例接受治疗、3例接受预防和1例用于观察不良反应的病例中，CTRX的疗效为良好至优异。观察到的不良反应包括4例腹泻和2例呕吐。作为异常实验室参数，各有1例出现嗜酸性粒细胞增多和血小板增多。3. 对9例患者的肠道细菌进行检查发现，CTRX对菌群的影响与其他第三代头孢菌素一样大。4. 对11例患者进行维生素K缺乏检查，发现3例凝血酶原时间（PT）延长，2例维生素K缺乏诱导蛋白（PIVKA）II呈阳性。5. 对7例患者用二磷酸腺苷（ADP）进行血小板聚集试验，结果显示CTRX影响很小。
