Song Yan-Jin, Wang Xu, Li Xin-Ju, Zhang Zhi-Long
Graduate School of Tianjin University of TCM, Tianjin 300193,China.
Department of Acupuncture and Moxibustion, Affiliated Hospital of Tianjin Academy of TCM, Tianjin 300120.
Zhongguo Zhen Jiu. 2020 Aug 12;40(8):811-5. doi: 10.13703/j.0255-2930.20190618-0001.
To observe the therapeutic effect of needling technique (acupuncture for regulating spleen and stomach) on diabetic gastroparesis (DGP), and to explore its possible mechanism.
A total of 128 patients with DGP were randomized into an observation group (64 cases, 4 cases dropped off) and a control group (64 cases, 4 cases dropped off). On the basis of intervention on controlling blood glucose by western medication, needling technique was adopted at Zhongwan (CV 12), Zusanli (ST 36), Yinlingquan (SP 9), Xuehai (SP 10), Sanyinjiao (SP 6), Diji (SP 8), etc. in the observation group, once a day. Mosapride citrate dispersible tablet 5 mg was given orally 3 times a day in the control group. The treatment was given 6 times a week in the both groups, and totally 4-week treatment was required. Before and after treatment, the DGP symptom score, serum content of transmembrane protein 16A (ANO1) were observed, and the clinical therapeutic effect and the safety were evaluated in the both groups.
After treatment, the each subitem score (belching, abdominal distension, inappetence, nausea and vomiting, epigastric pain, abnormal defecation) and the total score of DGP symptom were decreased in both groups (<0.05), the subitem scores of belching, abdominal distension, inappetence, nausea and vomiting and the total score in the observation group were lower than those in the control group (<0.05). After treatment, the serum contents of transmembrane protein 16A were reduced in both groups (<0.05), and that in the observation group was lower than the control group (<0.05). The total effective rate was 86.7% (52/60) in the observation group, which was superior to 70.0% (42/60) in the control group (<0.05). Subcutaneous hematoma occurred in 5 cases in the observation group, which was improved after cold compress without other particular intervention.
The therapeutic effect of needling technique on improving symptoms in patients with diabetic gastroparesis is superior to mosapride citrate dispersible tablet, its mechanism may be related to alleviating the damage of interstitial cells of Cajal (ICC).
观察针刺术（调脾胃针法）治疗糖尿病胃轻瘫（DGP）的疗效，并探讨其可能机制。
将128例DGP患者随机分为观察组（64例，脱落4例）和对照组（64例，脱落4例）。在西药控制血糖干预的基础上，观察组采用针刺中脘（CV 12）、足三里（ST 36）、阴陵泉（SP 9）、血海（SP 10）、三阴交（SP 6）、地机（SP 8）等穴位，每日1次。对照组口服枸橼酸莫沙必利分散片5 mg，每日3次。两组均每周治疗6次，共需治疗4周。观察两组治疗前后DGP症状评分、跨膜蛋白16A（ANO1）血清含量，并评价两组的临床疗效及安全性。
治疗后，两组DGP各分项评分（嗳气、腹胀、食欲不振、恶心呕吐、上腹部疼痛、排便异常）及症状总分均降低（P<0.05），观察组嗳气、腹胀、食欲不振、恶心呕吐分项评分及总分低于对照组（P<0.05）。治疗后，两组跨膜蛋白16A血清含量均降低（P<0.05），且观察组低于对照组（P<0.05）。观察组总有效率为86.7%（52/60），优于对照组的70.0%（42/60）（P<0.05）。观察组有5例出现皮下血肿，经冷敷后好转，未作其他特殊处理。
针刺术改善糖尿病胃轻瘫患者症状的疗效优于枸橼酸莫沙必利分散片，其机制可能与减轻 Cajal 间质细胞（ICC）损伤有关。
