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第二近红外辐射剂量计(NIR2D)系统,用于辐射剂量测量。

Second window near-infrared dosimeter (NIR2D) system for radiation dosimetry.

机构信息

Department of Radiation Oncology, Stanford University, Stanford, CA 94305, United States of America. These authors contributed equally to this work.

出版信息

Phys Med Biol. 2020 Aug 31;65(17):175013. doi: 10.1088/1361-6560/ab9b56.

Abstract

Fiber-coupled scintillation dosimeters are a cost-effective alternative to the conventional ion chambers in radiation dosimetry. However, stem effects from optical fibers such as Cerenkov radiation incur significant errors in the readout signal. Here we introduce a second near-infrared window dosimeter, dubbed as NIR2D, that can potentially be used as real-time radiation detector for clinical megavoltage beams. Lanthanide-based rare-earth NaYF nano-phosphors doped with both erbium and cerium elements were synthesized, and a compact 3D printed reader device integrated with a photodetector and data acquisition system was designed. The performance of the NIR2D was tested using a pre-clinical orthovoltage radiation source and a clinical megavoltage radiation source. The system was tested for dose linearity (100, 200, 600 MU), dose rate dependency (100, 200, 400, 600 MU min), and energy dependency (6, 10, 15 MV). Test results with the clinical linear accelerator demonstrated excellent dose linearity and dose rate independency when exposed to 6 MV linac beams-both data follows a linear trendline with R > 0.99. On the other hand, the NIR2D was energy dependent, where the readout dropped by 9% between 6 and 15 MV. For stem effects, we observed a finite Cerenkov contribution of 1%-3% when exposed between 100-600 MU min (6 MV) and 3%-6% when exposed between 5-15 MV (600 MU min). While the stem effects were still observable, we expect that enhancing the current optical setup will simultaneously improve the scintillation signal and reduce the stem effects.

摘要

光纤耦合闪烁体剂量计是辐射剂量学中传统电离室的一种具有成本效益的替代方案。然而,光纤的茎效应,如切伦科夫辐射,会导致读出信号产生显著误差。在这里,我们引入了第二种近红外窗口剂量计,称为 NIR2D,它有可能被用作临床兆伏射线的实时辐射探测器。合成了掺杂铒和铈元素的镧系稀土 NaYF 纳米荧光粉,并设计了一种集成光电探测器和数据采集系统的紧凑型 3D 打印读取器设备。使用临床前正交射线源和临床兆伏射线源测试了 NIR2D 的性能。该系统测试了剂量线性度(100、200、600MU)、剂量率依赖性(100、200、400、600MUmin)和能量依赖性(6、10、15MV)。用临床直线加速器进行的测试结果表明,当暴露于 6MV 直线加速器束时,剂量线性度和剂量率独立性非常好-数据都遵循线性趋势线,R>0.99。另一方面,NIR2D 是能量依赖性的,在 6 到 15MV 之间读数下降了 9%。对于茎效应,当暴露于 100-600MUmin(6MV)之间时,我们观察到有限的切伦科夫贡献为 1%-3%,当暴露于 5-15MV(600MUmin)之间时,贡献为 3%-6%。虽然茎效应仍然可以观察到,但我们预计增强当前的光学设置将同时提高闪烁信号并减少茎效应。

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