Bundgaard M
Institute of Medical Physiology, University of Copenhagen, Denmark.
Microcirc Endothelium Lymphatics. 1988 Apr;4(2):113-42.
Structural and functional data which can be ascribed to consecutive segments of the microvascular bed are reviewed and tentatively correlated. Compared to the knowledge of endothelial cells in general, little is known about segmental variations of the microvascular endothelium. The gradient in microvascular permeability has been quantified by single capillary techniques. The results conform to structural data on endothelial tight junctions which indicate that pathways through the junctions occur with increasing frequency towards the venous end of the microvascular bed. A number of compounds mediate gap formation in venular endothelium presumably via endothelial surface-receptors. It has been demonstrated that receptors to histamine are preferentially located at the luminal surface of venular endothelium. Immunocytochemical localization of metabolic activities of microvascular endothelium in situ has started; thus it has been shown that specific antibodies to xanthine oxidase bind only to endothelium of true capillaries.
对可归因于微血管床连续节段的结构和功能数据进行了综述并进行了初步关联。与一般内皮细胞的知识相比，关于微血管内皮的节段性变化知之甚少。微血管通透性梯度已通过单毛细管技术进行了量化。结果与内皮紧密连接的结构数据一致，表明通过连接的途径在微血管床的静脉端出现的频率增加。许多化合物可能通过内皮表面受体介导小静脉内皮中的间隙形成。已经证明组胺受体优先位于小静脉内皮的腔表面。微血管内皮原位代谢活性的免疫细胞化学定位已经开始；因此已经表明，针对黄嘌呤氧化酶的特异性抗体仅与真毛细血管的内皮结合。
