Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences, 18221 Prague, Czech Republic.
Institute for Clinical & Experimental Medicine (IKEM), 14021 Prague, Czech Republic.
Int J Mol Sci. 2020 Aug 28;21(17):6226. doi: 10.3390/ijms21176226.
The emerged field of non-thermal plasma (NTP) shows great potential in the alteration of cell redox status, which can be utilized as a promising therapeutic implication. In recent years, the NTP field considerably progresses in the modulation of immune cell function leading to promising in vivo results. In fact, understanding the underlying cellular mechanisms triggered by NTP remains incomplete. In order to boost the field closer to real-life clinical applications, there is a need for a critical overview of the current state-of-the-art. In this review, we conduct a critical analysis of the NTP-triggered modulation of immune cells. Importantly, we analyze pitfalls in the field and identify persisting challenges. We show that the identification of misconceptions opens a door to the development of a research strategy to overcome these limitations. Finally, we propose the idea that solving problems highlighted in this review will accelerate the clinical translation of NTP-based treatments.
新兴的非热等离子体（NTP）领域在改变细胞氧化还原状态方面显示出巨大的潜力，可作为一种有前途的治疗手段。近年来，NTP 领域在调节免疫细胞功能方面取得了相当大的进展，从而带来了有前景的体内结果。事实上，对 NTP 触发的细胞机制的理解还不完全。为了将该领域推向更接近现实临床应用的方向，需要对当前的最新技术进行批判性的综述。在这篇综述中，我们对 NTP 触发的免疫细胞调节进行了批判性分析。重要的是，我们分析了该领域的缺陷，并确定了持续存在的挑战。我们表明，识别误解为制定研究策略以克服这些限制打开了一扇门。最后，我们提出这样一种观点，即解决本文中强调的问题将加速基于 NTP 的治疗方法的临床转化。
