National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre (NIHR-SRMRC), University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham B15 2TH, UK.
Neuroscience & Ophthalmology Research Group, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Int J Mol Sci. 2020 Aug 29;21(17):6273. doi: 10.3390/ijms21176273.
Making decisions regarding return-to-play after sport-related concussion (SRC) based on resolution of symptoms alone can expose contact-sport athletes to further injury before their recovery is complete. Task-related functional near-infrared spectroscopy (fNIRS) could be used to scan for abnormalities in the brain activation patterns of SRC athletes and help clinicians to manage their return-to-play. This study aims to show a proof of concept of mapping brain activation, using tomographic task-related fNIRS, as part of the clinical assessment of acute SRC patients. A high-density frequency-domain optical device was used to scan 2 SRC patients, within 72 h from injury, during the execution of 3 neurocognitive tests used in clinical practice. The optical data were resolved into a tomographic reconstruction of the brain functional activation pattern, using diffuse optical tomography. Moreover, brain activity was inferred using single-subject statistical analyses. The advantages and limitations of the introduction of this optical technique into the clinical assessment of acute SRC patients are discussed.
基于症状的单一缓解来决定运动员重返赛场（RTP），可能会导致接触性运动的运动员在完全康复之前再次受伤。任务相关的近红外光谱（fNIRS）技术可用于扫描运动相关脑震荡（SRC）运动员的大脑激活模式异常，并帮助临床医生管理其重返赛场。本研究旨在展示一种概念验证，即使用断层任务相关 fNIRS 来映射大脑激活，作为急性 SRC 患者临床评估的一部分。高分辨率频域光学设备用于在损伤后 72 小时内扫描 2 名 SRC 患者，在此期间执行临床实践中使用的 3 项神经认知测试。使用漫射光学层析成像技术，将光学数据解析为大脑功能激活模式的断层重建。此外，还使用单个体统计分析来推断大脑活动。讨论了将这种光学技术引入急性 SRC 患者临床评估的优势和局限性。
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