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接受扩大性肺转移瘤切除术患者的生存及预后因素

Survival and prognostic factors in patients undergoing extended pulmonary metastasectomy.

作者信息

Kawaguchi Yo, Hanaoka Jun, Ohshio Yasuhiko, Okamoto Keigo, Kaku Ryosuke, Hayashi Kazuki, Shiratori Takuya, Yoden Makoto

机构信息

Division of General Thoracic Surgery, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.

Department of General Thoracic Surgery, Kusatsu General Hospital, Kusatsu, Shiga 525-8585, Japan.

出版信息

Mol Clin Oncol. 2020 Nov;13(5):48. doi: 10.3892/mco.2020.2118. Epub 2020 Aug 20.

Abstract

Extended pulmonary metastasectomy has become feasible in patients with extrapulmonary metastases and multiple or bilateral pulmonary metastases. Even peritoneal dissemination is considered to be curable in modern medicine. Therefore, it is necessary to analyze the prognosis of patients undergoing complete pulmonary metastasectomy. A total of 80 patients who underwent pulmonary resection for lung metastases were retrospectively analyzed. The eligibility criteria for the present study were as follows: i) the primary tumor was controlled; ii) if extrapulmonary metastases (including peritoneal dissemination) existed, these were controlled by local treatment or such treatment was planned; iii) the one to three months follow-up computed tomography (CT) following the first assessment revealed no increase of pulmonary metastatic disease; iv) pulmonary metastases could be resected completely. The overall 5- and 10-year survival rates were 71.7 and 41.5%, respectively. Applying the extended criteria for surgery, the present study demonstrated that pulmonary metastasectomy resulted in a good patient prognosis.

摘要

对于伴有肺外转移以及多发或双侧肺转移的患者,扩大性肺转移瘤切除术已变得可行。甚至在现代医学中,腹膜播散也被认为是可治愈的。因此,有必要分析接受完全性肺转移瘤切除术患者的预后情况。本研究对80例行肺转移瘤肺切除术的患者进行了回顾性分析。本研究的纳入标准如下:i)原发肿瘤得到控制;ii)若存在肺外转移(包括腹膜播散),这些转移灶通过局部治疗得到控制或已计划进行此类治疗;iii)首次评估后1至3个月的随访计算机断层扫描(CT)显示肺转移病灶未增加;iv)肺转移瘤可完全切除。总体5年和10年生存率分别为71.7%和41.5%。应用扩大的手术标准,本研究表明肺转移瘤切除术可使患者获得良好的预后。

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