别孕烯醇酮（1938 - 2019）：80年卓越科学成就的历程 - Suppr

Allopregnanolone (1938-2019): A trajectory of 80 years of outstanding scientific achievements.

作者信息

Pinna Graziano

机构信息

The Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 1601 W. Taylor Street, Chicago, IL, 60612, USA.

出版信息

Neurobiol Stress. 2020 Aug 5;13:100246. doi: 10.1016/j.ynstr.2020.100246. eCollection 2020 Nov.

DOI:10.1016/j.ynstr.2020.100246

PMID:32875009

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7451447/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9bc/7451447/691bf93f0e37/gr1.jpg

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Allopregnanolone (1938-2019): A trajectory of 80 years of outstanding scientific achievements.别孕烯醇酮（1938 - 2019）：80年卓越科学成就的历程

Neurobiol Stress. 2020 Aug 5;13:100246. doi: 10.1016/j.ynstr.2020.100246. eCollection 2020 Nov.

Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease.别孕烯醇酮的多效性作用是其在应激相关疾病中发挥治疗作用的基础。

Neurobiol Stress. 2019 Nov 27;12:100203. doi: 10.1016/j.ynstr.2019.100203. eCollection 2020 May.

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective.别孕烯醇酮：从分子病理生理学到治疗学。历史视角。

Neurobiol Stress. 2020 Mar 14;12:100215. doi: 10.1016/j.ynstr.2020.100215. eCollection 2020 May.

Changes of serum allopregnanolone levels in the first 2 years of life and during pubertal development.生命最初2年及青春期发育期间血清别孕烯醇酮水平的变化。

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Effects of allopregnanolone on sedation in men, and in women on oral contraceptives.别孕烯醇酮对男性镇静作用及对口服避孕药女性镇静作用的影响。

Psychoneuroendocrinology. 2007 Jun;32(5):555-64. doi: 10.1016/j.psyneuen.2007.03.009. Epub 2007 Apr 30.

[The scientific achievement of surgeon Ernst von Bergmann (1836-1907) in the development of medicine in reference to his correspondence in the years 1877-1878].[外科医生恩斯特·冯·贝格曼（1836 - 1907）在1877 - 1878年信件中所体现的医学发展方面的科学成就]

Beitr Orthop Traumatol. 1990 Jun;37(6):349-52.

The relationship between weight gain during pregnancy and allopregnanolone levels: a longitudinal study.孕期体重增加与别孕烯醇酮水平之间的关系：一项纵向研究。

Endocr Connect. 2017 May;6(4):253-259. doi: 10.1530/EC-17-0046. Epub 2017 Apr 5.

The effects of PK11195 on meningioma was associated with allopregnanolone biosynthesis, which was mediated by translocator protein 18 KDa.PK11195 对脑膜瘤的作用与异戊烯醇酮的生物合成有关，这是由 18 kDa 转位蛋白介导的。

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Allopregnanolone preferentially induces energy-rich food intake in male Wistar rats.别孕烯醇酮优先诱导雄性Wistar大鼠摄入富含能量的食物。

Physiol Rep. 2014 Dec 11;2(12). doi: 10.14814/phy2.12190. Print 2014 Dec 1.

Progesterone Exerts a Neuromodulatory Effect on Turning Behavior of Hemiparkinsonian Male Rats: Expression of 3 α -Hydroxysteroid Oxidoreductase and Allopregnanolone as Suggestive of GABAA Receptors Involvement.孕酮对偏侧帕金森病雄性大鼠的转向行为发挥神经调节作用：3α-羟基类固醇氧化还原酶和别孕烯醇酮的表达提示γ-氨基丁酸A型受体参与其中。

Parkinsons Dis. 2015;2015:431690. doi: 10.1155/2015/431690. Epub 2015 Mar 31.

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Local effect of allopregnanolone in rat ovarian steroidogenesis, follicular and corpora lutea development.孕烷醇酮对大鼠卵巢甾体生成、卵泡和黄体发育的局部作用。

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Neurosteroid [3α,5α]-3-hydroxy-pregnan-20-one enhances IL-10 production via endosomal TRIF-dependent TLR4 signaling pathway.神经甾体[3α,5α]-3-羟基孕烷-20-酮通过内体 TRIF 依赖性 TLR4 信号通路增强 IL-10 的产生。

Front Endocrinol (Lausanne). 2023 Dec 21;14:1299420. doi: 10.3389/fendo.2023.1299420. eCollection 2023.

New insights on the potential effect of progesterone in Covid-19: Anti-inflammatory and immunosuppressive effects.关于孕激素在 COVID-19 中潜在作用的新见解：抗炎和免疫抑制作用。

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Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression.针对γ-氨基丁酸-谷氨酸神经传递的药物疗法治疗难治性抑郁症

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Increased Voluntary Alcohol Consumption in Mice Lacking GABA Is Associated With Functional Changes in Hippocampal GABA Receptors.缺乏γ-氨基丁酸的小鼠自愿饮酒量增加与海马体γ-氨基丁酸受体的功能变化有关。

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Associations between PTSD-Related extinction retention deficits in women and plasma steroids that modulate brain GABA and NMDA receptor activity.女性创伤后应激障碍相关消退记忆保持缺陷与调节大脑γ-氨基丁酸（GABA）和N-甲基-D-天冬氨酸（NMDA）受体活性的血浆类固醇之间的关联。

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Composite contributions of cerebrospinal fluid GABAergic neurosteroids, neuropeptide Y and interleukin-6 to PTSD symptom severity in men with PTSD.脑脊液中γ-氨基丁酸能神经甾体、神经肽Y和白细胞介素-6对创伤后应激障碍男性患者创伤后应激障碍症状严重程度的综合影响。

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The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins.别孕烯醇酮在类抑郁行为中的作用：聚焦于神经营养蛋白。

Neurobiol Stress. 2020 Apr 9;12:100218. doi: 10.1016/j.ynstr.2020.100218. eCollection 2020 May.

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective.别孕烯醇酮：从分子病理生理学到治疗学。历史视角。

Neurobiol Stress. 2020 Mar 14;12:100215. doi: 10.1016/j.ynstr.2020.100215. eCollection 2020 May.

Allopregnanolone in premenstrual dysphoric disorder (PMDD): Evidence for dysregulated sensitivity to GABA-A receptor modulating neuroactive steroids across the menstrual cycle.经前烦躁障碍（PMDD）中的别孕烯醇酮：整个月经周期对γ-氨基丁酸A（GABA-A）受体调节神经活性甾体的敏感性失调的证据。

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Allopregnanolone in postpartum depression: Role in pathophysiology and treatment.别孕烯醇酮在产后抑郁症中的作用：在病理生理学及治疗中的角色

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Post-finasteride syndrome: An emerging clinical problem.非那雄胺后综合征：一个新出现的临床问题。

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Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse.大鼠出生后早期别孕烯醇酮水平变化与成年后行为紊乱：对药物滥用的启示

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Realising the therapeutic potential of neuroactive steroid modulators of the GABA receptor.认识到GABA受体神经活性甾体调节剂的治疗潜力。

Neurobiol Stress. 2019 Dec 23;12:100207. doi: 10.1016/j.ynstr.2019.100207. eCollection 2020 May.

PPAR and functional foods: Rationale for natural neurosteroid-based interventions for postpartum depression.过氧化物酶体增殖物激活受体与功能性食品：基于天然神经甾体干预产后抑郁症的理论依据。

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Allopregnanolone (1938-2019): A trajectory of 80 years of outstanding scientific achievements.

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