UCD School of Medicine and Medical Sciences, Dublin, Ireland.
Coombe Women and Infants University Hospital, Dublin, Ireland.
Acta Paediatr. 2021 Feb;110(2):433-440. doi: 10.1111/apa.15559. Epub 2020 Sep 28.
Necrotising enterocolitis (NEC) is a devastating condition with high morbidity and mortality seen predominately in preterm infants. Multiple factors are associated with the pathogenesis of NEC. The widespread use of antibiotics in the neonatal intensive care unit might play a role in the pathogenesis of NEC in preterm infants. This review provides a summary on the intestinal microbiota in preterm infants with a focus on how antibiotic exposure may reduce the biodiversity of the intestinal microbiota and may predispose preterm infants to NEC. CONCLUSION: Prolonged antibiotic therapy has been suggested as a risk factor for the development of NEC in preterm infants.
坏死性小肠结肠炎（NEC）是一种毁灭性疾病，发病率和死亡率都很高，主要见于早产儿。多种因素与 NEC 的发病机制有关。新生儿重症监护病房（NICU）中广泛使用抗生素可能在早产儿 NEC 的发病机制中发挥作用。本综述提供了关于早产儿肠道微生物组的概述，重点介绍了抗生素暴露如何减少肠道微生物组的多样性，并可能使早产儿易患 NEC。结论：长期抗生素治疗被认为是早产儿发生 NEC 的危险因素。
