Gelmers H J, Gorter K, de Weerdt C J, Wiezer H J
Department of Neurology, Streekziekenhuis, Almelo, the Netherlands.
Stroke. 1988 Jun;19(6):709-11. doi: 10.1161/01.str.19.6.709.
Quantitative assessment of patient data is a pertinent part of controlled clinical studies. When several centers are involved, the degree of agreement between different observers becomes important. Therefore, in addition to developing a multicenter study on acute ischemic stroke, we have estimated the interobserver agreement expressed in terms of kappa statistics. Twelve patients suffering from neurologic deficits due to acute ischemic stroke were examined by four investigators, and the results were assessed using the Mathew scale. Considerable interobserver variability was found. Agreement on items based on subjective information from the patient was low, and it is also possible that this information changes with time. It is advised that in the development of assessment scales, items with low interobserver agreement should be avoided.
对患者数据进行定量评估是对照临床研究的一个相关部分。当涉及多个中心时，不同观察者之间的一致程度就变得很重要。因此，除了开展一项关于急性缺血性中风的多中心研究外，我们还根据kappa统计量估计了观察者间的一致性。四名研究人员对12例因急性缺血性中风导致神经功能缺损的患者进行了检查，并使用马修量表对结果进行评估。发现观察者间存在相当大的变异性。基于患者主观信息的项目一致性较低，而且这些信息也有可能随时间而变化。建议在制定评估量表时，应避免使用观察者间一致性较低的项目。
