Hamberger C, Urien S, Barre J, Brandebourger M, Lemaire M, Lang P, Buisson C, Loisance D, Cachera J P, Lagrue G
Service Hospitalo-Universitaire de Pharmacologie, Centre Hospitalier Intercommunal, Creteil, France.
Ther Drug Monit. 1988;10(1):28-33.
The relationship between blood cells and plasma concentrations of cyclosporin A (Cy A) determined by radioimmunoassay, was investigated in 12 heart and 12 kidney transplant recipients. The decision between a linear and nonlinear model was made according to a standardized residuals plot. We observed high blood cells-plasma concentration ratios in the two groups, indicating a high affinity of Cy A for blood cells. The distribution of Cy A between blood cells and plasma was ascribed to a nonlinear saturable model in the two groups. According to our results we have simulated the blood-plasma concentration ratio of Cy A as a function of plasma Cy A concentration and hematocrit.
通过放射免疫分析法，对12名心脏移植受者和12名肾脏移植受者体内血细胞与环孢素A（Cy A）血浆浓度之间的关系进行了研究。根据标准化残差图来决定采用线性模型还是非线性模型。我们观察到两组中血细胞与血浆浓度之比都很高，这表明Cy A对血细胞具有高亲和力。两组中Cy A在血细胞和血浆之间的分布均归因于非线性饱和模型。根据我们的研究结果，我们模拟了Cy A的血-血浆浓度比与血浆Cy A浓度和血细胞比容之间的函数关系。
