Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, UK.
MRC Integrative Epidemiology Unit at the University of Bristol, UK.
J Musculoskelet Neuronal Interact. 2020 Sep 1;20(3):301-313.
Hip development is influenced by mechanical loading, but associations between prenatal loading and hip shape in later life remain unexplored.
We examined associations between prenatal loading indicators (gestation length, oligohydramnios (OH) and breech) obtained from obstetric records and hip shape modes (HSMs) generated using dual-energy X-ray absorptiometry images taken at age 14- and 18-years in participants from the UK Avon Longitudinal Study of Parents and Children (ALSPAC). These associations were examined in 2453 (30 OH, 105 breech) and 2330 (27 OH, 95 breech) participants with complete data at age 14- and 18-years respectively using confounder-adjusted models.
At 14 years HSM2 was 0.59SD lower in OH males, and HSM5 (-0.31SD) and HSM9 (-0.32SD) were lower in OH in both sexes. At 18 years HSM1 (-0.44SD) and HSM2 (-0.71SD) were lower and HSM6 (0.61SD) and HSM8 (1.06SD) were higher in OH males, whilst HSM5 was lower in OH in both sexes. OH appeared to be associated with a wider femoral neck and head, and larger lesser/greater trochanters. Only weak associations were observed between gestation length/breech and HSMs.
These results suggest that prenatal skeletal loading, in particular oligohydramnios, may influence adolescent joint shape with associations generally stronger in males.
髋关节的发育受到机械负荷的影响，但产前负荷与晚年髋关节形态之间的关系仍不清楚。
我们研究了从产科记录中获得的产前负荷指标（胎龄、羊水过少（OH）和臀位）与在参与者 14 岁和 18 岁时使用双能 X 射线吸收法（DXA）图像生成的髋关节形态模式（HSM）之间的关联，这些关联在英国阿冯纵向研究父母和儿童（ALSPAC）的参与者中进行了检查。在分别有完整的 14 岁和 18 岁数据的 2453 名（30 名 OH，105 名臀位）和 2330 名（27 名 OH，95 名臀位）参与者中，使用混杂因素调整模型检查了这些关联。
在 14 岁时，OH 男性的 HSM2 低 0.59SD，OH 男性和女性的 HSM5（-0.31SD）和 HSM9（-0.32SD）均较低。在 18 岁时，OH 男性的 HSM1（-0.44SD）和 HSM2（-0.71SD）较低，HSM6（0.61SD）和 HSM8（1.06SD）较高，而 OH 女性的 HSM5 较低。OH 似乎与股骨颈和头部较宽以及较小/较大转子较大有关。胎龄/臀位与 HSM 之间仅存在微弱关联。
这些结果表明，产前骨骼负荷，特别是羊水过少，可能会影响青少年关节形状，在男性中关联通常更强。
