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一项降低高血胆固醇的全国性计划。

A national program for lowering high blood cholesterol.

作者信息

Hulley S B

机构信息

Clinical Epidemiology Program, Institute for Health Policy Studies, San Francisco, CA.

出版信息

Am J Obstet Gynecol. 1988 Jun;158(6 Pt 2):1561-7. doi: 10.1016/0002-9378(88)90190-1.

Abstract

The National Institutes of Health have begun a new National Cholesterol Education Program. This program is modeled on the 15-year-old National High Blood Pressure Education Program, which has played a major role in improving the detection and treatment of hypertension in this country. Similar success can be predicted for the National Cholesterol Education Program, given the similarity between these two risk factors--hypertension and cholesterol--in (1) the accumulated scientific evidence for the benefit of intervention, (2) the availability of classification and treatment guidelines, and (3) the approach to professional and public health education programs. The new National Cholesterol Education Program guidelines recommend that all adults undergo a blood cholesterol measurement at least once every 5 years. Patients with a level greater than 200 mg/dl (confirmed by a second measurement) should be advised to adopt a step 1 fat-controlled diet. Patients with a cholesterol level greater than 240 mg/dl are candidates for intensive treatment with step 2 diet and sometimes drugs, as are those in the 200 to 240 mg/dl range who are at especially high risk because they already have coronary heart disease or two other risk factors. However, drugs for lowering blood cholesterol levels should be used only when the indication has been confirmed by measurements of low-density lipoprotein cholesterol and as a supplement to continuing the dietary treatment.

摘要

美国国立卫生研究院已启动一项新的国家胆固醇教育计划。该计划仿照已有15年历史的国家高血压教育计划制定,后者在改善该国高血压的检测和治疗方面发挥了重要作用。鉴于高血压和胆固醇这两个风险因素在以下方面存在相似性:(1)干预有益的累积科学证据;(2)分类和治疗指南的可用性;(3)专业和公共卫生教育计划的实施方法,预计国家胆固醇教育计划也会取得类似的成功。新的国家胆固醇教育计划指南建议,所有成年人应至少每5年进行一次血液胆固醇检测。胆固醇水平高于200毫克/分升(经第二次检测确认)的患者应被告知采用一级脂肪控制饮食。胆固醇水平高于240毫克/分升的患者,以及胆固醇水平在200至240毫克/分升之间但因已患有冠心病或存在其他两个风险因素而处于特别高风险的患者,是强化治疗的对象,强化治疗包括采用二级饮食,有时还需用药。然而,降低血液胆固醇水平的药物仅应在通过低密度脂蛋白胆固醇检测确认有用药指征时使用,并作为持续饮食治疗的补充。

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