Department of Psychology, School of Education, Heilongjiang University, China.
Department of Child Health Care, Maternity and Child Healthcare, Hospital of Nanshan District, Shenzhen, China.
Neural Plast. 2020 Aug 17;2020:7235734. doi: 10.1155/2020/7235734. eCollection 2020.
We explored the face classification processing mechanism in depressed patients, especially the biases of happy faces in face classification processing of depression. Thirty patients with the first episode of depression at the First Affiliated Hospital of Harbin Medical University were selected as the depression group, while healthy people matched for age, gender, and educational level were assigned to the control group. The Hamilton Depression Scale and Hamilton Anxiety Scale were used to select the subjects; then, we used the forced face classification paradigm to collect behavioral (response time and accuracy) and event-related potential (ERP) data of the subjects. The differences between the groups were estimated using a repeated measurement analysis of variance. The total response time of classified faces in the depression group was longer than that in the control group, the correct rate was lower, and the difference was statistically significant ( < 0.05). N170 component analysis demonstrated that the latency of the depression group was prolonged, and the difference was statistically significant ( < 0.05). When classifying happy faces, the depressed patients demonstrated a decrease in N170 amplitude and a prolongation of latency in some brain regions compared with the healthy individuals. The cognitive bias in depression may be due to prolonged processing of positive facial information and difficulty in producing positive emotional responses.
我们探讨了抑郁症患者的面部分类处理机制，特别是在抑郁患者对面部分类处理中对快乐面孔的偏见。选取哈尔滨医科大学附属第一医院首发抑郁症患者 30 例作为抑郁症组，按年龄、性别、文化程度相匹配的健康人作为对照组。采用汉密尔顿抑郁量表和汉密尔顿焦虑量表进行入组筛选，然后采用强制性面孔分类范式收集被试的行为（反应时和准确率）和事件相关电位（ERP）数据。采用重复测量方差分析估计组间差异。与对照组相比，抑郁症组分类面孔的总反应时延长，准确率降低，差异有统计学意义（<0.05）。N170 成分分析表明，抑郁症组潜伏期延长，差异有统计学意义（<0.05）。在分类快乐面孔时，与健康个体相比，抑郁症患者在一些脑区的 N170 振幅减小，潜伏期延长。抑郁症患者的认知偏差可能是由于对正面面部信息的处理时间延长，以及产生积极情绪反应的困难所致。
