Division of Neurology, Neurology Imaging Unit, Hammersmith Hospital, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
J Neurol. 2021 Feb;268(2):582-589. doi: 10.1007/s00415-020-10204-y. Epub 2020 Sep 2.
Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson's disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. C-PE2I non-displaceable binding potential (BP) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal C-PE2I BP over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.
纹状体多巴胺能缺陷和运动症状的不对称是特发性帕金森病（PD）的典型特征。本研究旨在描述中晚期 PD 中不对称性的趋势。我们对 27 名患者进行了为期 19 个月的纵向研究，包括 PET-CT 成像和适当的临床评估。在基线和随访时，我们对纹状体进行双侧 C-PE2I 不可置换结合潜能（BP）计算，以估计纹状体多巴胺转运体（DAT）的体内密度。与对侧相比，同侧纹状体 C-PE2I BP 随时间的变化更为明显。运动障碍协会统一帕金森病评定量表（MDS-UPDRS-III）的运动成分（运动部分）的变化在临床最受影响和最不受影响的身体侧之间没有差异。我们的数据支持在中晚期 PD 中，纹状体多巴胺能退化的不对称性变得不那么明显。相反，在此期间，在临床最受影响和最不受影响的身体侧之间，运动症状的不对称性得到维持。
