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[抗血管内皮生长因子疗法治疗血管样条纹继发新生血管形成(一例报告)]

[Anti-VEGF therapy in the treatment of neovascularization secondary to angioid streaks (a case report)].

作者信息

Shelankova A V, Budzinskaya M V

机构信息

Research Institute of Eye Diseases, Moscow, Russia.

出版信息

Vestn Oftalmol. 2020;136(4. Vyp. 2):219-225. doi: 10.17116/oftalma2020136042219.

Abstract

The article presents a clinical case of using anti-VEGF therapy in the treatment of retinal neovascularization consequent to angioid streaks (AS). Angioid streaks are linear breaks or divergences in an abnormally brittle or calcified Bruch's membrane. The development of choroidal neovascularization (CNV) due to AS is one of the most serious complications of the disease and the main cause of visual impairment, especially in active middle-aged patients. Currently, determination of the morphology and activity of CNV is done using multimodal macular imaging methods such as optical coherence tomography of the retina (OCT), optical coherence tomography angiography (OCT-A), fluorescin angiography (FA), indocyanine green angiography (ICGA) and autofluorescence. With the discovery of anti-VEGF therapy, it became possible to improve and stabilize functional results in this group of patients.

摘要

本文介绍了使用抗血管内皮生长因子(VEGF)疗法治疗因血管样条纹(AS)导致的视网膜新生血管的临床病例。血管样条纹是异常脆弱或钙化的布鲁赫膜中的线性断裂或分支。由AS引起的脉络膜新生血管(CNV)的发展是该疾病最严重的并发症之一,也是视力损害的主要原因,尤其是在活跃的中年患者中。目前,使用多模式黄斑成像方法,如视网膜光学相干断层扫描(OCT)、光学相干断层扫描血管造影(OCT-A)、荧光素血管造影(FA)、吲哚菁绿血管造影(ICGA)和自发荧光,来确定CNV的形态和活性。随着抗VEGF疗法的发现,改善和稳定这组患者的功能结果成为可能。

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