Department of Obstetrics and Gynecology, Aichi Medical University School of Medicine, Nagakute, Japan.
Climacteric. 2021 Apr;24(2):164-170. doi: 10.1080/13697137.2020.1806815. Epub 2020 Sep 3.
This study aimed to evaluate the effects of royal jelly (RJ) supplementation on bone metabolism in postmenopausal women.
This was a randomized, double-blind, placebo-controlled clinical trial. Seventy-two healthy postmenopausal women aged 45-60 years within 5 years after menopause were randomized into two groups: women in the RJ group ( = 36) received capsules containing dried RJ (equivalent to 3000 mg of fresh RJ); and women in the placebo group ( = 36) received placebo daily for 6 months. Bone mineral density (BMD) of the lumbar spine (L2-L4) and left proximal femur, hip structural analysis (HSA) of the left hip, and bone turnover markers were measured.
Although women in the placebo group experienced a significant loss of BMD and deterioration in HSA parameters of the femur, no significant differences were found in these parameters in women in the RJ group. The levels of total procollagen type 1 N-terminal propeptide (P1NP) and tartrate-resistant acid phosphatase decreased significantly in the placebo group; however, the total P1NP level, a marker of bone formation, was not significantly different in the RJ group at postintervention compared with baseline.
RJ consumption may ameliorate decreases in femoral BMD and strength in postmenopausal women.
本研究旨在评估蜂王浆（RJ）补充对绝经后妇女骨代谢的影响。
这是一项随机、双盲、安慰剂对照的临床试验。72 名年龄在 45-60 岁、绝经后 5 年内的健康绝经后妇女被随机分为两组：RJ 组（n=36）服用含有干 RJ（相当于 3000mg 新鲜 RJ）的胶囊；安慰剂组（n=36）每天服用安慰剂，持续 6 个月。测量腰椎（L2-L4）和左侧股骨近端骨矿物质密度（BMD）、左侧髋部结构分析（HSA）和骨转换标志物。
虽然安慰剂组妇女的 BMD 显著下降，股骨 HSA 参数恶化，但 RJ 组妇女的这些参数无显著差异。安慰剂组总 1 型前胶原 N 端前肽（P1NP）和抗酒石酸酸性磷酸酶水平显著下降；然而，与基线相比，干预后 RJ 组的总 P1NP 水平（骨形成标志物）无显著差异。
RJ 摄入可能改善绝经后妇女股骨 BMD 和强度的下降。
