Cerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.
Department of Neurology, Alfried Krupp Hospital, Essen, Germany.
Neurol Sci. 2020 Dec;41(Suppl 2):439-446. doi: 10.1007/s10072-020-04645-6.
Although migraine is generally considered an idiopathic and isolated neurological condition, it may also represent the presenting symptom of several uncommon heritable and acquired neurological diseases contributing to the recognition of such conditions. Migraine may indeed present with atypical characteristics or prolonged duration and may be associated with specific neuroradiological findings that may help in identifying the underlying condition. However, features of migraine in rare diseases are usually little known because of the lack of systematic studies. The aim of this paper is to provide clinicians with an updated review on specific clinical and neuroradiological features of migraine in uncommon neurological diseases that may be helpful to their diagnosis and treatment. Therefore, the early diagnosis of these uncommon diseases is crucial for patients' clinical management and for the implementation of therapeutic approaches aimed at targeting the underlying disease pathogenic mechanisms. Thus, when investigating patients affected by migraine, physicians should always be aware about rare causes of migraine that if misdiagnosed could seriously impact patients' outcome. Given these relevant implications, future studies specifically assessing features of migraine in uncommon diseases are mandatory.
虽然偏头痛通常被认为是一种特发性和孤立的神经系统疾病，但它也可能代表几种罕见的遗传性和获得性神经系统疾病的表现症状，这些疾病有助于识别此类疾病。偏头痛确实可能表现出非典型特征或持续时间延长，并且可能与特定的神经影像学发现相关，这些发现可能有助于确定潜在疾病。然而，由于缺乏系统研究，罕见疾病中偏头痛的特征通常鲜为人知。本文的目的是为临床医生提供偏头痛在罕见神经系统疾病中的特定临床和神经影像学特征的最新综述，这可能有助于其诊断和治疗。因此，这些罕见疾病的早期诊断对患者的临床管理和实施针对潜在疾病发病机制的治疗方法至关重要。因此，当调查偏头痛患者时，医生应始终意识到偏头痛的罕见原因，如果误诊可能会严重影响患者的预后。鉴于这些相关影响，专门评估罕见疾病中偏头痛特征的未来研究是强制性的。
