Krieger J, Imbs J L, Schmidt M, Kurtz D
EEG Department, University Hospital, Strasbourg, France.
Arch Intern Med. 1988 Jun;148(6):1337-40.
Patients with obstructive sleep apnea (OSA) often exhibit nocturnal polyuria, which disappears with nasal continuous positive airway pressure (CPAP) treatment. We measured water and electrolyte urinary excretion, creatinine and osmolal clearances, and water transport during sleep in 13 polygraphically monitored patients with OSA during two consecutive nights, either untreated or treated with nasal CPAP, and in eight normal subjects. Untreated patients with OSA had greater urinary flows and greater urinary sodium, chloride, and potassium excretions than did controls. Nasal CPAP treatment in patients with OSA resulted in a reduction in urinary flow and in sodium and chloride excretion, with a concomitant increase in sodium resorption. None of these effects was observed in CPAP-treated normal subjects. The only effect of nasal CPAP common to normal subjects and patients was a trend toward decreased glomerular filtration rate.
阻塞性睡眠呼吸暂停（OSA）患者常出现夜间多尿，经鼻持续气道正压通气（CPAP）治疗后多尿症状消失。我们对13例经多导睡眠监测的OSA患者在连续两晚未治疗及经鼻CPAP治疗期间的睡眠中尿液水和电解质排泄、肌酐及渗透清除率以及水转运情况进行了测量，并与8名正常受试者进行了对比。未经治疗的OSA患者比对照组有更高的尿流量以及更高的尿钠、氯和钾排泄量。OSA患者经鼻CPAP治疗后尿流量以及钠和氯排泄量减少，同时钠重吸收增加。在接受CPAP治疗的正常受试者中未观察到这些效应。正常受试者和患者中经鼻CPAP共同的唯一效应是肾小球滤过率有降低趋势。
