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检测人类胆固醇代谢的一种调控机制:精氨酸和甘氨酸与胰岛素及胰高血糖素的关系。

Testing a mechanism of control in human cholesterol metabolism: relation of arginine and glycine to insulin and glucagon.

作者信息

Sanchez A, Hubbard R W, Smit E, Hilton G F

机构信息

School of Public Health; Department of Pathology, Loma Linda University, CA 92350.

出版信息

Atherosclerosis. 1988 May;71(1):87-92. doi: 10.1016/0021-9150(88)90306-1.

DOI:10.1016/0021-9150(88)90306-1
PMID:3288227
Abstract

Eight men were given 2 casein meals, one with and one without a supplement of arginine and glycine, to measure the effect on plasma amino acids, insulin and glucagon. Supplementation resulted in increased levels of plasma glucagon, glycine and arginine, a tendency to decreased insulin and significantly lower insulin/glucagon ratio, tryptophan and tyrosine. The data suggest that insulin and glucagon, which control cholesterol metabolism, respond to dietary and postprandial plasma amino acid levels of arginine and glycine.

摘要

八名男性分别食用了两顿酪蛋白餐,一顿添加了精氨酸和甘氨酸,另一顿未添加,以测定其对血浆氨基酸、胰岛素和胰高血糖素的影响。添加后导致血浆胰高血糖素、甘氨酸和精氨酸水平升高,胰岛素有下降趋势,胰岛素/胰高血糖素比值、色氨酸和酪氨酸显著降低。数据表明,控制胆固醇代谢的胰岛素和胰高血糖素对饮食和餐后血浆中精氨酸和甘氨酸的氨基酸水平有反应。

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1
Testing a mechanism of control in human cholesterol metabolism: relation of arginine and glycine to insulin and glucagon.检测人类胆固醇代谢的一种调控机制:精氨酸和甘氨酸与胰岛素及胰高血糖素的关系。
Atherosclerosis. 1988 May;71(1):87-92. doi: 10.1016/0021-9150(88)90306-1.
2
Plasma amino acids and the insulin/glucagon ratio as an explanation for the dietary protein modulation of atherosclerosis.血浆氨基酸和胰岛素/胰高血糖素比值作为动脉粥样硬化饮食蛋白质调节的一种解释。
Med Hypotheses. 1991 Aug;35(4):324-9. doi: 10.1016/0306-9877(91)90278-7.
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Plasma amino acids and the insulin/glucagon ratio as an explanation for the dietary protein modulation of atherosclerosis.血浆氨基酸与胰岛素/胰高血糖素比值作为动脉粥样硬化膳食蛋白质调节的一种解释。
Med Hypotheses. 1991 Sep;36(1):27-32. doi: 10.1016/0306-9877(91)90160-z.
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Hypocholesterolemic amino acids and the insulin glucagon ratio.降胆固醇氨基酸与胰岛素-胰高血糖素比值
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Effects of arginine and lysine addition to casein and soya-bean protein on serum lipids, apolipoproteins, insulin and glucagon in rats.向酪蛋白和大豆蛋白中添加精氨酸和赖氨酸对大鼠血脂、载脂蛋白、胰岛素和胰高血糖素的影响。
Br J Nutr. 1982 Sep;48(2):211-21. doi: 10.1079/bjn19820107.
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Contribution of postprandial amino acid levels to stimulation of insulin, glucagon, and pancreatic polypeptide in humans.餐后氨基酸水平对人体胰岛素、胰高血糖素和胰多肽分泌刺激的作用。
Pancreas. 1992;7(6):698-704. doi: 10.1097/00006676-199211000-00011.
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Dietary protein-dependent modification of serum cholesterol level in rats. Significance of the arginine/lysine ratio.大鼠血清胆固醇水平的膳食蛋白质依赖性修饰。精氨酸/赖氨酸比值的意义。
Ann Nutr Metab. 1984;28(3):192-9. doi: 10.1159/000176803.
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The metabolic response to ingested glycine.
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Plasma glucagon and insulin responses depend on the rate of appearance of amino acids after ingestion of different protein solutions in humans.在人类摄入不同蛋白质溶液后,血浆胰高血糖素和胰岛素反应取决于氨基酸的出现速率。
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Effect of dietary protein on serum insulin and glucagon levels in hyper- and normocholesterolemic men.膳食蛋白质对高胆固醇血症和正常胆固醇血症男性血清胰岛素和胰高血糖素水平的影响。
Atherosclerosis. 1989 Mar;76(1):55-61. doi: 10.1016/0021-9150(89)90193-7.

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