Aulas Anaïs, Finetti Pascal, Lyons Shawn M, Bertucci François, Birnbaum Daniel, Acquaviva Claire, Mamessier Emilie
Predictive Oncology Laboratory, Cancer Research Center of Marseille (CRCM), Inserm U1068, CNRS UMR7258, Institut Paoli-Calmettes, Aix Marseille Université, 13009 Marseille, France.
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
Cancers (Basel). 2020 Sep 1;12(9):2470. doi: 10.3390/cancers12092470.
Cancer treatments are constantly evolving with new approaches to improve patient outcomes. Despite progresses, too many patients remain refractory to treatment due to either the development of resistance to therapeutic drugs and/or metastasis occurrence. Growing evidence suggests that these two barriers are due to transient survival mechanisms that are similar to those observed during stress response. We review the literature and current available open databases to study the potential role of stress response and, most particularly, the involvement of Stress Granules (proteins) in cancer. We propose that Stress Granule proteins may have prognostic value for patients.
癌症治疗方法不断演进,新方法致力于改善患者预后。尽管取得了进展,但仍有太多患者因对治疗药物产生耐药性和/或发生转移而对治疗无效。越来越多的证据表明,这两个障碍归因于类似于应激反应中观察到的短暂生存机制。我们回顾了文献和当前可用的开放数据库,以研究应激反应的潜在作用,尤其是应激颗粒(蛋白质)在癌症中的作用。我们认为应激颗粒蛋白可能对患者具有预后价值。