Stram Amanda R, Kesler Kenneth A
Department of Surgery, Division of Cardiothoracic Surgery, Indiana University Melvin and Bren Simon Cancer Center, 545 Barnhill Drive, Indianapolis, IN 46202, USA; Department of Surgery, Thoracic Surgery Division, Indiana University, 545 Barnhill Drive, Indianapolis, IN 46202, USA.
Department of Surgery, Division of Cardiothoracic Surgery, Indiana University Melvin and Bren Simon Cancer Center, 545 Barnhill Drive EM #212, Indianapolis, IN 46202, USA; Department of Surgery, Thoracic Surgery Division, Indiana University, 545 Barnhill Drive EM #212, Indianapolis, IN 46202, USA.
Surg Oncol Clin N Am. 2020 Oct;29(4):571-579. doi: 10.1016/j.soc.2020.06.005. Epub 2020 Jul 20.
Primary mediastinal nonseminomatous germ cell tumors represent a rare but important malignancy that occurs in otherwise young and healthy patients. Treatment is challenging and involves cisplatin-based chemotherapy followed by surgery to remove residual disease. Avoiding bleomycin-containing chemotherapy in the treatment of primary mediastinal nonseminomatous germ cell tumors is important. Prechemotherapy and postchemotherapy pathology as well as postoperative serum tumor markers are independent predictors of long-term survival.
原发性纵隔非精原细胞性生殖细胞肿瘤是一种罕见但重要的恶性肿瘤，发生于其他方面年轻且健康的患者。治疗具有挑战性，包括以顺铂为基础的化疗，随后进行手术以切除残留病灶。在原发性纵隔非精原细胞性生殖细胞肿瘤的治疗中避免使用含博来霉素的化疗很重要。化疗前和化疗后的病理以及术后血清肿瘤标志物是长期生存的独立预测因素。
