Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Sex Med Rev. 2021 Jul;9(3):423-433. doi: 10.1016/j.sxmr.2020.07.004. Epub 2020 Sep 1.
Information about the possible effects of cutaneous immune-mediated diseases (cIMDs) on male sexual function and reproduction is scarce. Factors known to impair sexual health and reproduction, such as inflammation, medication use, and hypogonadism, can be present in a significant proportion of male patients with cIMD.
To systematically review the literature for the influence of paternal cIMD on many aspects of male sexual and reproductive health, such as sexual function, reproductive hormones, fertility, and pregnancy and offspring outcomes.
A systematic literature search was performed. The searches combined keywords regarding male sexual function and fertility, pregnancy outcomes, and offspring's health with a list of cIMDs.
The majority of the identified studies included patients with psoriasis (22 of 27), and sexual function was the most common outcome of interest (20 of 27). For patients diagnosed with psoriasis, the prevalence of male sexual dysfunction reported in these studies ranged from 34 to 81%. Hypogonadism in patients with psoriasis was reported in 2 of 3 studies. Sperm analysis abnormalities in patients with psoriasis were reported in 3 of 4 studies. No information about the effect of paternal disease on pregnancy and offspring outcomes was identified.
Disease activity in psoriasis might play an important role in the development of sexual dysfunction, hypogonadism, and abnormal sperm quality. For the other cIMD included in this review, there is insufficient information regarding male sexual and reproductive health to draw firm conclusions. More research is needed to understand the association between cIMD and impaired male sexual and reproductive health. Perez-Garcia LF, Dolhain R, te Winkel B, et al. Male Sexual Health and Reproduction in Cutaneous Immune-Mediated Diseases: A Systematic Review. Sex Med Rev 2021;9:423-433.
有关皮肤免疫介导性疾病（cIMD）对男性性功能和生殖功能影响的信息很少。已知会损害男性的性健康和生殖功能的因素，如炎症、药物使用和性腺功能减退症，在很大一部分患有 cIMD 的男性患者中都会出现。
系统回顾文献，以了解 cIMD 对男性性功能和生殖健康诸多方面的影响，如性功能、生殖激素、生育能力以及妊娠和后代结局。
进行了系统的文献检索。检索将与男性性功能和生育力、妊娠结局以及后代健康相关的关键词与一系列 cIMD 相结合。
确定的大多数研究都包括银屑病患者（27 项研究中的 22 项），而性功能是最常见的研究结果（27 项研究中的 20 项）。在诊断为银屑病的患者中，这些研究报告的男性性功能障碍的患病率范围为 34%至 81%。在 3 项研究中有 2 项报告了银屑病患者的性腺功能减退症。在 4 项研究中有 3 项报告了银屑病患者的精子分析异常。没有关于父源性疾病对妊娠和后代结局影响的信息。
银屑病的疾病活动可能在性功能障碍、性腺功能减退症和精子质量异常的发展中起重要作用。对于本综述中包括的其他 cIMD，关于男性性功能和生殖健康的信息不足，无法得出明确的结论。需要进一步的研究来了解 cIMD 与受损的男性性功能和生殖健康之间的关联。Perez-Garcia LF、Dolhain R、te Winkel B 等人。皮肤免疫介导性疾病中的男性性健康和生殖：系统评价。性医学评论 2021;9:423-433。
