John R, Henley R, Lloyd G, Elder G H
Department of Medical Biochemistry, University Hospital of Wales, Health Park, Cardiff, U.K.
Clin Chem. 1988 Jun;34(6):1110-4.
We assessed the use of a new strategy for detecting thyroid disorders, utilizing a sensitive assay for concentrations of thyrotropin (TSH) and free thyroid hormone in serum as follow-up tests. Of 1279 patients who were not on thyroxin (T4) replacement treatment, 82% could be classified as euthyroid and would require no further tests. In patients who were on T4 replacement, 41% fell into the euthyroid category and would require no further tests. Using this strategy to replace our existing strategy of free thyroxin as a "first-line" test would reduce the proportion of patients who would require one or more follow-up tests from 49% to 24%.
我们评估了一种检测甲状腺疾病的新策略，该策略利用一种灵敏的检测方法测定血清促甲状腺激素（TSH）和游离甲状腺激素的浓度作为后续检测。在1279名未接受甲状腺素（T4）替代治疗的患者中，82%可归类为甲状腺功能正常，无需进一步检测。在接受T4替代治疗的患者中，41%属于甲状腺功能正常类别，无需进一步检测。使用该策略取代我们现有的游离甲状腺素“一线”检测策略，将使需要进行一次或多次后续检测的患者比例从49%降至24%。
