Boissy R E
Department of Dermatology, University of Cincinnati College of Medicine, Ohio.
Dermatol Clin. 1988 Apr;6(2):161-73.
I would like to stress that there seem to be three subpopulations of neural crest-derived melanocytes in the body that can be functionally and morphologically distinguished: the cutaneous melanocytes, which continuously synthesize small melanosomes to be transferred to keratinocytes; the uveal melanocytes, which synthesize larger melanosomes for only a short while to be retained by this melanogenically dormant cell; and the hair melanocyte, which intermittently produces melanin either in a cyclic manner or as a periodic supply from a stem population. These three types of melanocytes synthesize melanin granules by an identical bipartite system. However, the control mechanism regulating the specific differentiation and postmelanin synthesis function of these cell types needs to be addressed in future research.
我想强调的是，体内似乎存在三种源自神经嵴的黑素细胞亚群，它们在功能和形态上可以区分：皮肤黑素细胞，持续合成小黑素体并将其转移至角质形成细胞；葡萄膜黑素细胞，仅在短时间内合成较大的黑素体，并被这种处于黑素生成休眠状态的细胞保留；以及毛发黑素细胞，以周期性方式或作为来自干细胞群体的周期性供应间歇性地产生黑色素。这三种类型的黑素细胞通过相同的二分系统合成黑色素颗粒。然而，调节这些细胞类型的特定分化和黑色素合成后功能的控制机制需要在未来的研究中加以探讨。
