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广泛心肌内出血合并急性心肌梗死尸检病例报告

An autopsy case report of extensive intramyocardial hemorrhage complicated with acute myocardial infarction.

作者信息

Oka Satoshi, Nakamura Jun, Kai Takahiko, Hoshino Katsuomi, Watanabe Kazunori, Abe Makoto, Yasuda Kazuyo, Watanabe Akinori

机构信息

Department of Cardiology, Fujieda Municipal General Hospital, Japan.

Department of Pathology, Fujieda Municipal General Hospital, Japan.

出版信息

J Cardiol Cases. 2020 Jun 24;22(3):121-124. doi: 10.1016/j.jccase.2020.05.021. eCollection 2020 Sep.

Abstract

Hemorrhagic myocardial infarction (HMI) is a complication associated with percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). We carried out a successful PCI for a 59-year old Japanese man presenting with chest pain due to AMI over 5 h. The onset to balloon time was 363 min. The next morning, he suffered cardiogenic shock, even with an auxiliary circulating device, which eventually resulted in death. An autopsy revealed extensive HMI. The necrotic myocardium showed not only coagulation necrosis but also contraction band necrosis which suggests myocardial injury due to late reperfusion. Although the intramyocardial hemorrhage was confined to the necrotic area, it was beyond the perfusion area of the culprit artery. Here, we describe a case of death with severe HMI. HMI can be a serious complication and worsen prognosis. < The aim of primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) is to recanalize the infarct related artery and salvage the ischemic myocardium. However, late reperfusion sometimes leads to hemorrhagic myocardial infarction (HMI) as a result of myocardial injury. To avoid extensive HMI in AMI patients, primary PCI should be performed as soon as possible.>.

摘要

出血性心肌梗死(HMI)是急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)相关的一种并发症。我们对一名59岁因AMI出现胸痛超过5小时的日本男性成功实施了PCI。从发病到球囊扩张时间为363分钟。第二天早晨,即便使用了辅助循环装置,他仍发生了心源性休克,最终导致死亡。尸检显示广泛的HMI。坏死心肌不仅表现为凝固性坏死,还出现了收缩带坏死,提示存在晚期再灌注导致的心肌损伤。尽管心肌内出血局限于坏死区域,但超出了罪犯血管的灌注区域。在此,我们描述一例因严重HMI死亡的病例。HMI可能是一种严重并发症并使预后恶化。<急性心肌梗死(AMI)的直接经皮冠状动脉介入治疗(PCI)的目的是使梗死相关动脉再通并挽救缺血心肌。然而,晚期再灌注有时会因心肌损伤导致出血性心肌梗死(HMI)。为避免AMI患者发生广泛的HMI,应尽早进行直接PCI。>

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Myocardial reperfusion injury.心肌再灌注损伤
N Engl J Med. 2007 Sep 13;357(11):1121-35. doi: 10.1056/NEJMra071667.

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