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沙库巴曲缬沙坦治疗植入式心脏复律除颤器患者的逆向重构及心律失常负荷降低：病例报告

Reverse remodeling and arrhythmic burden reduction in a patient with an implantable cardioverter defibrillator treated with sacubitril/valsartan: Case report.

作者信息

Corrado Egle, Saladino Antonino, Morgante Giusy, Mignano Antonino, Nugara Cinzia, Novo Giuseppina, Coppola Giuseppe

机构信息

UTIC - Cardiologia Policlinico Universitario Paolo Giaccone Palermo Italy.

出版信息

Clin Case Rep. 2020 Jun 9;8(8):1349-1352. doi: 10.1002/ccr3.2655. eCollection 2020 Aug.

DOI:10.1002/ccr3.2655
PMID:32884751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7455401/
Abstract

Sacubitril/valsartan has been shown to reduce cardiovascular mortality and hospitalizations in patients with HFrEF when compared to enalapril. There are also some evidences of its potential antiarrhythmic effects. We present a report where we found a relation between reverse ventricular remodeling and arrhythmic reduction in a patient treated with sacubitril/valsartan.

摘要

与依那普利相比，沙库巴曲缬沙坦已被证明可降低射血分数降低的心力衰竭（HFrEF）患者的心血管死亡率和住院率。也有一些证据表明其具有潜在的抗心律失常作用。我们报告了一例使用沙库巴曲缬沙坦治疗的患者，发现其逆向心室重构与心律失常减少之间存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d7a/7455401/4e2e6ffd8655/CCR3-8-1349-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d7a/7455401/dca7b435bd63/CCR3-8-1349-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d7a/7455401/4e2e6ffd8655/CCR3-8-1349-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d7a/7455401/dca7b435bd63/CCR3-8-1349-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d7a/7455401/4e2e6ffd8655/CCR3-8-1349-g002.jpg

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引用本文的文献

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Eur J Clin Pharmacol. 2022 Jan;78(1):19-25. doi: 10.1007/s00228-021-03210-0. Epub 2021 Sep 23.

本文引用的文献

1
Reverse remodeling in Dilated Cardiomyopathy: Insights and future perspectives.扩张型心肌病中的逆向重构：见解与未来展望。
Int J Cardiol Heart Vasc. 2018 Mar 8;18:52-57. doi: 10.1016/j.ijcha.2018.02.005. eCollection 2018 Mar.
2
Effects of angiotensin-neprilysin inhibition compared to angiotensin inhibition on ventricular arrhythmias in reduced ejection fraction patients under continuous remote monitoring of implantable defibrillator devices.在植入式除颤设备连续远程监测下，比较血管紧张素-脑啡肽酶抑制与血管紧张素抑制对射血分数降低患者室性心律失常的影响。
Heart Rhythm. 2018 Mar;15(3):395-402. doi: 10.1016/j.hrthm.2017.11.012. Epub 2017 Nov 14.
3
Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach.
沙库巴曲缬沙坦对心脏重塑的作用机制：一种系统生物学方法。
NPJ Syst Biol Appl. 2017 Apr 18;3:12. doi: 10.1038/s41540-017-0013-4. eCollection 2017.
4
Non-responders to cardiac resynchronization therapy: Insights from multimodality imaging and electrocardiography. A brief review.心脏再同步治疗无反应者：多模态成像和心电图的见解。简要综述。
Int J Cardiol. 2016 Dec 15;225:402-407. doi: 10.1016/j.ijcard.2016.09.037. Epub 2016 Sep 17.
5
Magnitude of QRS duration reduction after biventricular pacing identifies responders to cardiac resynchronization therapy.双心室起搏后QRS波时限缩短的幅度可识别心脏再同步治疗的反应者。
Int J Cardiol. 2016 Oct 15;221:450-5. doi: 10.1016/j.ijcard.2016.06.203. Epub 2016 Jul 1.
6
Recent advances in echocardiography: strain and strain rate imaging.超声心动图的最新进展：应变与应变率成像
F1000Res. 2016 Apr 29;5. doi: 10.12688/f1000research.7228.1. eCollection 2016.
7
Influence of Ejection Fraction on Outcomes and Efficacy of Sacubitril/Valsartan (LCZ696) in Heart Failure with Reduced Ejection Fraction: The Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) Trial.射血分数对沙库巴曲缬沙坦（LCZ696）治疗射血分数降低的心力衰竭的疗效及预后的影响：ARNI与ACEI对心力衰竭全球死亡率和发病率影响的前瞻性比较（PARADIGM-HF）试验
Circ Heart Fail. 2016 Mar;9(3):e002744. doi: 10.1161/CIRCHEARTFAILURE.115.002744.
8
Angiotensin-neprilysin inhibition versus enalapril in heart failure.血管紧张素-脑啡肽酶抑制剂与依那普利治疗心力衰竭的比较。
N Engl J Med. 2014 Sep 11;371(11):993-1004. doi: 10.1056/NEJMoa1409077. Epub 2014 Aug 30.
9
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Pacing Clin Electrophysiol. 2009 Aug;32(8):1092-5. doi: 10.1111/j.1540-8159.2009.02443.x.