Kusadasi Nuray, Sikma Maaike, Huisman Albert, Westerink Jan, Maas Coen, Schutgens Roger
Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Dutch Poisons Information Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Hemasphere. 2020 Aug 10;4(4):e457. doi: 10.1097/HS9.0000000000000457. eCollection 2020 Aug.
Recent evidence is focusing on the presence of a hypercoagulable state with development of both venous and arterial thromboembolic complications in patients infected with SARS-CoV-2. The ongoing activation of coagulation related to the severity of the illness is further characterized by thrombotic microangiopathy and endotheliitis. These microangiopathic changes cannot be classified as classical disseminated intravascular coagulation (DIC). In this short review we describe the interaction between coagulation and inflammation with focus on the possible mechanisms that might be involved in SARS-CoV-2 infection associated coagulopathy in the critically ill.
最近的证据聚焦于感染SARS-CoV-2的患者中存在高凝状态，并伴有静脉和动脉血栓栓塞并发症。与疾病严重程度相关的凝血持续激活，其特征还表现为血栓性微血管病和血管内皮炎。这些微血管病变不能归类为经典的弥散性血管内凝血（DIC）。在这篇简短的综述中，我们描述了凝血与炎症之间的相互作用，重点关注可能参与重症患者SARS-CoV-2感染相关凝血病的潜在机制。
