Department of Neurophysiology, Faculty of Medicine, Oita University, Idaigaoka 1-1, Yufu City, Oita, 879-5593, Japan.
J Bone Miner Metab. 2021 Jan;39(1):64-70. doi: 10.1007/s00774-020-01143-9. Epub 2020 Sep 4.
The receptor-activator of NF-κB ligand (RANKL) and its specific receptor RANK have essential roles in regulating bone metabolism and the immune system. Besides, the RANKL/RANK system plays important roles in multiple physiological and pathophysiological processes such as mammary gland development during pregnancy, cancer development, and bone metastasis. While it has long been known that RANKL and RANK are expressed in the central nervous system (CNS), the physiological roles of RANKL/RANK system in the CNS and the underlying molecular mechanisms have been elucidated recently. Over the last decade, several reports showed that the central RANKL/RANK system plays important roles in regulating body temperature, brain ischemia, autoimmune encephalopathy, feeding behavior, and energy metabolism. In this review, it is provided an updated information regarding the roles of RANKL/RANK system in the CNS.
核因子-κB 配体（RANKL）受体激活剂及其特异性受体 RANK 在调节骨代谢和免疫系统方面发挥着重要作用。此外，RANKL/RANK 系统在多种生理和病理生理过程中发挥着重要作用，如妊娠期间的乳腺发育、癌症发展和骨转移。虽然人们早就知道 RANKL 和 RANK 表达于中枢神经系统（CNS），但是 RANKL/RANK 系统在中枢神经系统中的生理作用及其潜在的分子机制最近才被阐明。在过去的十年中，有几项报道表明中枢 RANKL/RANK 系统在调节体温、脑缺血、自身免疫性脑病、摄食行为和能量代谢方面发挥着重要作用。在这篇综述中，提供了有关 RANKL/RANK 系统在中枢神经系统中的作用的最新信息。
