Lee J S, Fallon T, Hunter M, Ye Q A, Lee L P
Department of Biomedical Engineering, University of Virginia, Charlottesville 22908.
J Biomech Eng. 1988 May;110(2):150-4. doi: 10.1115/1.3108420.
We measured the density variations of aortic blood from rabbits ventilated by a positive end inspiratory pressure of 6 mmHg or a negative box pressure of the same magnitude. When calculated from the density variations, the fluctuations in blood volume of the pulmonary capillaries within one cycle as induced by an intermittent positive pressure ventilation were found to be similar to the ones induced by an intermittent negative pressure ventilation. Using these volumetric fluctuations as a means to assess the transpulmonary pressure and the transmural pressure across the pulmonary capillaries, we conclude that the switching of the ventilation method did not alter the cyclic fluctuations of these pressures.
我们测量了通过6 mmHg的吸气末正压或相同幅度的箱内负压通气的兔子主动脉血的密度变化。根据密度变化计算得出，间歇性正压通气引起的一个周期内肺毛细血管血容量波动与间歇性负压通气引起的相似。利用这些容积波动作为评估跨肺压和肺毛细血管跨壁压的手段，我们得出结论，通气方法的切换并未改变这些压力的周期性波动。
