Simon Gábor, Heckmann Veronika, Tóth Dénes, Pauka Dénes, Petrus Karola, Molnár Tamás F
Department of Forensic Medicine, Medical School, University of Pécs, Pécs, Hungary.
Department of Forensic Medicine, Medical School, University of Pécs, Pécs, Hungary.
Leg Med (Tokyo). 2020 Nov;47:101781. doi: 10.1016/j.legalmed.2020.101781. Epub 2020 Aug 29.
The liver is the most commonly injured abdominal organ, accounting for around half of abdominal organ injuries. The emergence of liver injury is determined by the injury mechanism, force, and tissue vulnerability. The vulnerability of the liver depends on the strength of the capsule and parenchyma, as well as the weight and dimensions of the liver. The common hepatic diseases, like steatosis, fibrosis, and cirrhosis, can change the organ weight and dimensions, but their exact correlation is not well known. This study was designed to evaluate the correlation between liver diseases, weight, and dimensions. The liver weight, horizontal, vertical, and antero-posterior length were measured obtained by 213 forensic autopsies. The recorded data were compared with body height, age, and liver histology. Body height positively correlated with liver weight (R = 0.252), but the correlation was much stronger in the case of livers without structural disease (R = 0.450). The liver size seems to significantly decrease with age (R = 0.081), but the effect is mostly due to structural alterations that are proven by histology. The comparison of the liver weight in various histological groups clearly indicated that steatosis increases the liver size, but fibrosis does not (if no steatosis is present at the same time). In general, liver dimensions increase proportionally to the liver weight. However, hepatic steatosis causes disproportional enlargement: it does not have a significant effect on the horizontal dimension and has only a minor effect on the vertical dimension. Steatosis affects disproportionally the dimensions with a strange tendency to expand liver anteroposteriorly.
肝脏是腹部最常受伤的器官，约占腹部器官损伤的一半。肝损伤的发生取决于损伤机制、外力和组织易损性。肝脏的易损性取决于包膜和实质的强度，以及肝脏的重量和尺寸。常见的肝脏疾病，如脂肪变性、纤维化和肝硬化，可改变肝脏的重量和尺寸，但其确切相关性尚不清楚。本研究旨在评估肝脏疾病、重量和尺寸之间的相关性。通过213例法医尸检测量了肝脏重量、水平、垂直和前后长度。将记录的数据与身高、年龄和肝脏组织学进行比较。身高与肝脏重量呈正相关（R = 0.252），但在无结构疾病的肝脏中相关性更强（R = 0.450）。肝脏大小似乎随年龄显著减小（R = 0.081），但这种影响主要是由于组织学证实的结构改变。不同组织学组肝脏重量的比较清楚地表明，脂肪变性会增加肝脏大小，但纤维化不会（如果同时不存在脂肪变性）。一般来说，肝脏尺寸与肝脏重量成比例增加。然而，肝脂肪变性会导致不成比例的增大：它对水平尺寸没有显著影响，对垂直尺寸只有轻微影响。脂肪变性对尺寸的影响不成比例，有一种奇怪的倾向，即使肝脏前后径增大。
