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发作性未来思维可降低慢性疼痛严重程度:概念验证研究。

Episodic future thinking reduces chronic pain severity: A proof of concept study.

机构信息

Center for Transformative Research on Health Behaviors, 1 Riverside Circle, Roanoke, VA 24016, United States; Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, 1 Riverside Circle, Roanoke, VA 24016, United States; Fralin Biomedical Research Institute at VTC, 2 Riverside Circle, Roanoke, VA 24016, United States.

Center for Transformative Research on Health Behaviors, 1 Riverside Circle, Roanoke, VA 24016, United States; Department of Statistics, Virginia Tech, Blacksburg, VA 24061, United States.

出版信息

Drug Alcohol Depend. 2020 Oct 1;215:108250. doi: 10.1016/j.drugalcdep.2020.108250. Epub 2020 Aug 25.

Abstract

BACKGROUND

Chronic pain is a major public health challenge in the United States and around the world. Current treatments including opioid analgesics and cognitive behavioral therapy possess harmful side effects or limited efficacy, respectively. Chronic pain is associated with a variety of unhealthy behaviors including opioid misuse. Moreover, individuals who suffer from chronic pain exhibit excessive discounting of delayed rewards, suggesting a constricted temporal window of valuation. Reductions in the excessive discounting of delayed rewards has been achieved with Episodic Future Thinking (EFT; vividly imagining realistic future events). EFT has also been associated with reductions in a variety of unhealthy behaviors. In this study, the effects of EFT on delay discounting and levels of pain were investigated in individuals reporting chronic pain.

METHODS

Individuals reporting chronic pain (N = 250; 42.4 % female) were recruited through the Amazon Mechanical Turk platform. Measures of delay discounting and pain were collected at baseline and again after randomization to EFT (N = 128) or Control Episodic Thinking (CET) (N = 122).

RESULTS

EFT significantly reduced delay discounting relative to baseline (p < 0.001) and EFT reduced pain scores in a baseline dependent manner (p = 0.001) when compared to CET; that is, those with the greatest reports of pain experienced the greatest reduction. Furthermore the reduction in delay discounting fully mediated the reduction in pain.

CONCLUSIONS

These findings suggest that Episodic Future Thinking, by widening the temporal window, may reduce pain in those reporting chronic pain and therefore represents a potential novel therapeutic.

摘要

背景

慢性疼痛是美国和全球的一个主要公共卫生挑战。目前的治疗方法包括阿片类镇痛药和认知行为疗法,分别具有有害的副作用或有限的疗效。慢性疼痛与包括阿片类药物滥用在内的各种不健康行为有关。此外,患有慢性疼痛的个体表现出对延迟奖励的过度折扣,表明他们的估值时间窗口狭窄。通过情景式未来思维(EFT;生动地想象现实的未来事件)可以减少对延迟奖励的过度折扣。EFT 还与减少各种不健康行为有关。在这项研究中,研究了 EFT 对报告慢性疼痛的个体的延迟折扣和疼痛水平的影响。

方法

通过亚马逊 Mechanical Turk 平台招募报告慢性疼痛的个体(N = 250;42.4%为女性)。在随机分配到 EFT(N = 128)或对照情景式思维(CET)(N = 122)后,收集延迟折扣和疼痛的测量值。

结果

EFT 显著降低了延迟折扣(p < 0.001),并且 EFT 以基线依赖的方式降低了疼痛评分(p = 0.001)与 CET 相比;也就是说,报告疼痛最严重的人经历了最大的缓解。此外,延迟折扣的减少完全介导了疼痛的减少。

结论

这些发现表明,情景式未来思维通过拓宽时间窗口,可能会减轻报告慢性疼痛的人的疼痛,因此代表了一种潜在的新型治疗方法。

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