急性心肌梗死患者外周血白细胞线粒体功能状态的特点

Peculiarities of the Functional State of Mitochondria of Peripheral Blood Leukocytes in Patients with Acute Myocardial Infarction.

作者信息

Afanas'ev S А, Muslimova E F, Rebrova Т Yu, Tsapko L P, Kercheva М А, Golubenko М V

机构信息

Сardiology Research Institute, Тomsk, Russia.

Research Institute of Medical Genetics, Тomsk National Research Medical Center, Russian Academy of Sciences, Тomsk, Russia.

出版信息

Bull Exp Biol Med. 2020 Aug;169(4):435-437. doi: 10.1007/s10517-020-04903-9. Epub 2020 Sep 5.

DOI:10.1007/s10517-020-04903-9

PMID:32889567

Abstract

We studied the rate of oxygen consumption by mitochondria isolated from peripheral blood leukocytes of patients with acute myocardial infarction and healthy volunteers. It was found that leukocyte mitochondria in patients with acute myocardial infarction were characterized by significantly lower rate of oxygen consumption and lower level of coupling of oxidation and phosphorylation processes in comparison with mitochondria from healthy volunteers.

摘要

我们研究了从急性心肌梗死患者和健康志愿者外周血白细胞中分离出的线粒体的氧消耗率。结果发现，与健康志愿者的线粒体相比，急性心肌梗死患者的白细胞线粒体具有明显较低的氧消耗率以及氧化与磷酸化过程的偶联水平。