Sun In O, Kwon Soon Hyo
Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju.
Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.
Curr Opin Nephrol Hypertens. 2020 Nov;29(6):613-619. doi: 10.1097/MNH.0000000000000641.
There has been an increasing interest in extracellular vesicles as potential diagnostic, prognostic or therapeutic biomarkers for various kidney diseases, as extracellular vesicles mediate cell-cell or intercellular communication. This review explores the current state of knowledge regarding extracellular vesicles as a tool for examining kidney physiology and disease.
Urinary extracellular vesicles may be useful as biomarkers to detect abnormal function in renal endothelial and tubular cells as well as podocytes. Recent studies suggest that urinary extracellular vesicles may facilitate early diagnosis and/or monitoring in acute kidney injury, glomerular disease, autosomal dominanat polycyst kidney disease and urinary tract malignancies. Circulating extracellular vesicles may serve as biomarkers to assess cardiovascular disease.
Urinary and circulating extracellular vesicles have gained significant interest as potential biomarkers of renal diseases. Analysis of extracellular vesicles may serve as a logical diagnostic approach for nephrologists as well as provide information about disease pathophysiology.
细胞外囊泡作为多种肾脏疾病潜在的诊断、预后或治疗生物标志物受到越来越多的关注，因为细胞外囊泡介导细胞间通讯。本综述探讨了关于细胞外囊泡作为研究肾脏生理学和疾病工具的当前知识状态。
尿细胞外囊泡可能作为生物标志物，用于检测肾内皮细胞、肾小管细胞以及足细胞的异常功能。最近的研究表明，尿细胞外囊泡可能有助于急性肾损伤、肾小球疾病、常染色体显性多囊肾病和尿路恶性肿瘤的早期诊断和/或监测。循环细胞外囊泡可能作为评估心血管疾病的生物标志物。
尿和循环细胞外囊泡作为肾脏疾病潜在的生物标志物已引起广泛关注。细胞外囊泡分析可能是肾病学家一种合理的诊断方法，并能提供有关疾病病理生理学的信息。
