Institute for Occupational, Social and Environmental Medicine, Medical Faculty (Mr Brand, Mr Beilmann, Mr Kraus, Ms Krabbe, Ms Merizian); Institut für Schweiß- und Fügetechnik (ISF) Welding and Joining Institute (Mr Krichel, Ms Schmidt), Rheinisch Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany.
J Occup Environ Med. 2020 Sep;62(9):718-723. doi: 10.1097/JOM.0000000000001946.
: Copper and zinc containing welding fumes are able to induce systemic inflammation in healthy subjects. In this study the no observed effect levels (NOEL) for welding fumes containing either copper or zinc were assessed.Fifteen healthy male volunteers participated in an exposure. Each subject was exposed to two different concentrations of both, copper and zinc containing welding fumes. Exposure was performed in the Aachen Workplace Simulation Lab.The NOEL was found at metal concentrations between 0.2 and 0.3 mg/m for copper and between 0.8 and 1.2 mg/m for zinc.The NOEL identified in this study was about a factor of 10 higher than the German workplace threshold limit values (TLV). However, TLV in other countries was in the same range or even higher than the NOEL indicating a considerable risk for workers.
含铜和锌的焊接烟尘能够在健康受试者中引起全身炎症。在这项研究中，评估了含铜或锌的焊接烟尘的无观察到不良效应水平（NOEL）。15 名健康男性志愿者参加了暴露实验。每个受试者都暴露于两种不同浓度的含铜和锌的焊接烟尘中。暴露实验在亚琛工作场所模拟实验室进行。NOEL 是在金属浓度为 0.2 到 0.3mg/m 之间的铜和 0.8 到 1.2mg/m 之间的锌时被发现的。本研究中确定的 NOEL 比德国工作场所的阈值限值（TLV）高约 10 倍。然而，其他国家的 TLV 处于相同范围或甚至高于 NOEL，这表明工人面临相当大的风险。
