Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Clin Neurol Neurosurg. 2020 Oct;197:106197. doi: 10.1016/j.clineuro.2020.106197. Epub 2020 Aug 29.
Multiple Sclerosis (MS) is a disease of the central nervous system, which ultimately may lead to various disabilities in patients. No definitive cure has yet been developed for the disease. MRI is the method of choice for imaging MS plaques, which would be useful in disease diagnosis as it becomes progressive. Therefore, this study aimed to investigate the serum levels of ANT1 (adenine nucleotide translocase 1), ATG5 (autophagy-related protein 5), and Parkin in patients with MS, all of which play essential roles in MS pathophysiology, as novel serum biomarkers for early diagnosis of the disease.
Forty patients in the early stages of the disease, and 40 healthy individuals were selected as the case and control groups. Upon sampling, the serum levels of the biomarkers were measured.
The results indicated that autophagy, mitophagy, and mitochondrial apoptosis were different in the case and control groups. The oxidative stress level evaluation revealed low concertation of total antioxidant status (TAS) in the MS patients, while a partial increase accompanied the malondialdehyde (MDA). No significant correlation was observed between oxidative stress and autophagy or mitophagy factors.
According to the results obtained from this study, the evaluation of serum levels of ANT1, ATG5, and Parkin could be applied in the diagnosis and follow-up of MS patients.
多发性硬化症（MS）是一种中枢神经系统疾病，最终可能导致患者出现各种残疾。目前尚未开发出针对该疾病的明确治愈方法。MRI 是用于成像 MS 斑块的首选方法，因为它在疾病进展时有助于进行诊断。因此，本研究旨在探讨 MS 患者血清中 ANT1（腺嘌呤核苷酸转位酶 1）、ATG5（自噬相关蛋白 5）和 Parkin 的水平，这些物质在 MS 病理生理学中发挥着重要作用，可作为该疾病早期诊断的新型血清生物标志物。
选择 40 名处于疾病早期的患者和 40 名健康个体作为病例组和对照组。在采样时，测量了生物标志物的血清水平。
结果表明，病例组和对照组之间的自噬、线粒体自噬和线粒体凋亡存在差异。氧化应激水平评估显示 MS 患者的总抗氧化状态（TAS）浓度较低，而丙二醛（MDA）则略有增加。氧化应激与自噬或线粒体自噬因子之间没有显著相关性。
根据本研究的结果，评估血清中 ANT1、ATG5 和 Parkin 的水平可应用于 MS 患者的诊断和随访。
