Beutin L, Prada J, Zimmermann S, Stephan R, Orskov I, Orskov F
Robert Koch-Institut des Bundesgesundheitsamtes, Berlin, West Germany.
Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Mar;267(4):576-88. doi: 10.1016/s0176-6724(88)80042-7.
42 Escherichia coli O26 strains which had been isolated at geographically different places and over a long time period were examined for hemolysin synthesis. 17 of these were found to be hemolysin-negative, nine strains were found to produce plasmid encoded alpha-hemolysin and 16 strains were shown to produce a phenotypically different hemolysin. This new type of hemolysin was called enterohemolysin and found to be genetically and immunologically non-related with the already described E. coli alpha-hemolysin. Enterohemolytic E. coli were not found in feces of 200 healthy infants under the age of two years. However, four E. coli O111 strains, one O121:H- and one O25:K5:H- strain, all from infants with diarrhoea were also enterohemolysin producers.
对42株在不同地理位置、经过较长时间分离得到的大肠杆菌O26菌株进行了溶血素合成检测。其中17株被发现为溶血素阴性，9株产生质粒编码的α-溶血素，16株产生一种表型不同的溶血素。这种新型溶血素被称为肠溶血素，发现其在基因和免疫方面与已描述的大肠杆菌α-溶血素无关。在200名两岁以下健康婴儿的粪便中未发现肠溶血大肠杆菌。然而，4株大肠杆菌O111菌株、1株O121:H-菌株和1株O25:K5:H-菌株，均来自腹泻婴儿，也产肠溶血素。
