Tian Yi-Min, Zhou Xin, Zhao Chao, Chen Hua-Guo, Gong Xiao-Jian
Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University Guiyang 550001, China Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, Guizhou Normal University Guiyang 550001, China Research Center for Quality Control of Natural Medicine, Guizhou Normal University Guiyang 550001, China.
Zhongguo Zhong Yao Za Zhi. 2020 Aug;45(15):3584-3593. doi: 10.19540/j.cnki.cjcmm.20200426.602.
Gastric cancer is a disease with high mortality, which threatens the health of people for a long time. At present, the main treatment methods are surgery and chemotherapy, but these methods have great harm to the human body. However, it is found that the active ingredients of traditional Chinese medicine have an obvious therapeutic effect in the adjuvant treatment of the tumor. Therefore, the active ingredients of traditional Chinese medicine have become a research hotspot in the anti-tumor field. In recent years, many related researchers have been particularly active in studying the in vitro activity and mechanism of active ingredients of traditional Chinese medicine on human gastric cancer cells. In this paper, the Chinese herbal medicine extracts, polysaccharides, alkaloids, saponins, flavones, terpenes, quinones, volatile oils, esters, phenols, protein components and other active ingredients of Chinese medicine were used as the starting points to investigate the anti-gastric cancer mechanism, such as inhibiting cell proliferation and inducing apoptosis of cancer cells, inhibiting cell invasion and migration; inhibiting over-expression of vascular endothelial growth factor(VEGF); interfering with cell mitosis; and regulating cell signaling pathways. Their in vitro inhibitory activity and mechanism for gastric cancer cells were described in this study, providing a theoretical reference for the development and application of anti-gastric cancer drugs.
胃癌是一种死亡率很高的疾病，长期威胁着人们的健康。目前，主要的治疗方法是手术和化疗，但这些方法对人体有很大危害。然而，人们发现中药活性成分在肿瘤的辅助治疗中具有明显的治疗效果。因此，中药活性成分已成为抗肿瘤领域的研究热点。近年来，许多相关研究人员在研究中药活性成分对人胃癌细胞的体外活性及作用机制方面表现得尤为活跃。本文以中草药提取物、多糖、生物碱、皂苷、黄酮、萜类、醌类、挥发油、酯类、酚类、蛋白质成分等中药活性成分为切入点，探讨其抗胃癌机制，如抑制细胞增殖、诱导癌细胞凋亡、抑制细胞侵袭和迁移；抑制血管内皮生长因子（VEGF）的过度表达；干扰细胞有丝分裂；调节细胞信号通路等。本研究阐述了它们对胃癌细胞的体外抑制活性及作用机制，为抗胃癌药物的开发应用提供理论参考。
