Hao Jin Yong, Jiang Tao, Huang Xiao Jun
Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
J Coll Physicians Surg Pak. 2020 Aug;30(8):868-870. doi: 10.29271/jcpsp.2020.08.868.
Glyphosate is a widely used herbicide. Acute glyphosate poisoning is not uncommon, mostly caused by a large amount of glyphosate entering the human body in a short time, and the common reason is taking it accidently. The manifestations of acute stage are mainly gastrointestinal reactions. The patient in the present study took glyphosate accidently. In the acute stage, the patient presented with nausea and vomiting, but no gastrointestinal bleeding or perforation was found. Upper gastrointestinal obstruction occurred after two months. Endoscopy revealed no abnormalities in the esophagus, but revealed multiple gastric scar changes, and pyloric obstruction. In addition, active gastric ulcer was also observed. Therefore, the choice of gastric lavage method, avoidance of neutralising acid-base reactions, and the long-term use of acid suppression and mucosal protection therapy may have important therapeutic implications for the repair of gastric mucosa in such cases. Key Words: Glyphosate, Ulceration, Pyloric obstruction.
草甘膦是一种广泛使用的除草剂。急性草甘膦中毒并不罕见，主要是由于大量草甘膦在短时间内进入人体，常见原因是误服。急性期表现主要为胃肠道反应。本研究中的患者误服了草甘膦。急性期患者出现恶心、呕吐，但未发现胃肠道出血或穿孔。两个月后发生上消化道梗阻。内镜检查显示食管无异常，但发现多处胃瘢痕改变及幽门梗阻。此外，还观察到活动性胃溃疡。因此，选择洗胃方法、避免酸碱中和反应以及长期使用抑酸和黏膜保护治疗可能对此类病例胃黏膜的修复具有重要的治疗意义。关键词：草甘膦；溃疡；幽门梗阻
