Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado, USA.
Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
Vet Comp Oncol. 2021 Dec;19(4):735-742. doi: 10.1111/vco.12652. Epub 2020 Sep 21.
Osteosarcoma (OSA) arising from the digits, metatarsal and metacarpal bones is rare and may carry a better prognosis compared with other locations. The aim of this study was to retrospectively evaluate the biological behaviour, the progression free interval (PFI), the survival time (ST) and evaluate the effect of adjuvant chemotherapy for OSA affecting these bones. Medical records from two academic institutions were reviewed and 15 cases were included. Descriptive statistics were used for signalment and history. For estimation of median PFI and median ST, the Kaplan-Meier method was utilized. The prognostic effect of chemotherapy, lymphocyte and monocyte count was investigated. Log-rank analysis was used to compare PFI and ST between groups. The overall median PFI and median ST were 377 and 687 days, respectively. No significant differences were noted for any of the variables evaluated. In this study, dogs affected by OSA of digits, metacarpal and metatarsal bones appear to have a longer ST compared with dogs with OSA of other appendicular locations. A study with a larger number of patients is needed to confirm these results and investigate the potential benefit of adjuvant chemotherapy.
发生于指骨、跖骨和掌骨的骨肉瘤（OSA）较为罕见，相较于其他部位，其预后可能更好。本研究旨在回顾性评估影响这些骨骼的骨肉瘤的生物学行为、无进展间隔时间（PFI）、生存时间（ST），并评估辅助化疗的效果。对两家学术机构的病历进行了回顾，并纳入了 15 例病例。对一般情况和病史进行了描述性统计分析。采用 Kaplan-Meier 法估计中位 PFI 和中位 ST。研究了化疗、淋巴细胞和单核细胞计数对预后的影响。采用对数秩检验比较组间 PFI 和 ST 的差异。总体中位 PFI 和中位 ST 分别为 377 天和 687 天。评估的任何变量均无显著差异。在本研究中，发生于指骨、掌骨和跖骨的 OSA 犬的 ST 似乎比发生于其他附肢部位的 OSA 犬更长。需要进行一项包含更多患者的研究来证实这些结果，并探讨辅助化疗的潜在获益。
