Li Juxiao, Yao Jingzhi, Xia Wei, Dai Jiayin, Liu Hongxiu, Pan Yitao, Xu Shunqing, Lu Shi, Jin Shuna, Li Yuanyuan, Sun Xiaojie, Zhang Bin, Zheng Tongzhang, Jiang Yangqian, Jing Tao
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, PR China.
Int J Hyg Environ Health. 2020 Sep;230:113596. doi: 10.1016/j.ijheh.2020.113596. Epub 2020 Sep 5.
Increasing evidence shows that exposure to per- and polyfluoroalkyl substances (PFASs), common and persistent anthropogenic pollutants, may affect glucose homeostasis. However, data is limited for pregnant women, and it is less clear how novel fluorinated pollutants affect glucose homeostasis during pregnancy. Our goal was to investigate the relationships of exposure to13 PFASs including some novel fluorinated pollutants with blood glucose in 874 Chinese pregnant women from the general population. We measured blood glucose following an oral glucose tolerance test (OGTT) in the second trimester and quantified PFAS concentrations in umbilical cord blood. The associations of PFAS exposure with fasting, 1-h OGTT and 2-h OGTT glucose were examined using the general linear regression model. For every doubling of perfluorobutane sulfonate (PFBS), a short-chain PFAS, the 1-h and 2-h OGTT blood glucose increased 0.09 mmol/L (β = 0.09, 95%CI: 0.02, 0.17) and 0.07 mmol/L (β = 0.07, 95%CI: 0.01, 0.13), respectively. In addition, perfluoroheptanoate (PFHpA), an alternative of perfluorooctanoate (PFOA), was positively associated with fasting glucose (β = 0.07, 95%CI: 0.02, 0.13; high vs low). Higher levels of PFAS exposure were related to increased blood glucose in pregnant women, indicating PFAS exposure may impair glucose homeostasis during pregnancy.
越来越多的证据表明，接触全氟和多氟烷基物质（PFASs）这种常见且持久的人为污染物可能会影响葡萄糖稳态。然而，针对孕妇的数据有限，新型氟化污染物如何在孕期影响葡萄糖稳态也不太清楚。我们的目标是调查874名来自普通人群的中国孕妇接触包括一些新型氟化污染物在内的13种PFASs与血糖之间的关系。我们在孕中期进行口服葡萄糖耐量试验（OGTT）后测量血糖，并对脐带血中的PFAS浓度进行定量。使用一般线性回归模型检验PFAS暴露与空腹、OGTT 1小时和OGTT 2小时血糖之间的关联。对于短链PFAS全氟丁烷磺酸（PFBS）每增加一倍，OGTT 1小时和2小时血糖分别升高0.09 mmol/L（β = 0.09，95%CI：0.02，0.17）和0.07 mmol/L（β = 0.07，95%CI：0.01，0.13）。此外，全氟辛酸（PFOA）的替代品全氟庚酸（PFHpA）与空腹血糖呈正相关（β = 0.07，95%CI：0.02，0.13；高暴露组与低暴露组）。更高水平的PFAS暴露与孕妇血糖升高有关，表明PFAS暴露可能会损害孕期的葡萄糖稳态。
